Comparisons of left atrial functional parameters with left ventricular diastolic dysfunction in a large taiwanese population with normal left ventricular ejection fraction according to age
Journal
Acta Cardiologica Sinica
Journal Volume
36
Journal Issue
6
Pages
633-640
Date Issued
2020
Author(s)
Abstract
Background: Recent studies have shown that left atrial (LA) volume is a sensitive morphophysiological indicator of the severity of LV dysfunction and may also be a useful index of cardiovascular risk. In this study, we performed comparisons among left atrial (LA) functional parameters for predicting age-related diastolic dysfunction. Methods: Echocardiography was performed in 2248 healthy participants with a low possibility of heart disease according to the decennium of age, and reference values were established. Progressive diastolic dysfunction paralleled increasing age and could be well identified by traditional and advanced echocardiographic parameters, including mitral inflow pattern, tissue Doppler parameters, and LA volume. Results: Regarding LA functional parameters analyzed based on the decennium of age, left atrial ejection fraction (LAEF) and emptying fraction could not represent aging diastolic dysfunction well, but LA expansion index ((Volmax – Volmin) ? 100% / Volmin) could. Volmax indicated maximal LA volume and Volmin indicated minimal LA volume. In assessments of diastolic dysfunction with receiver operating characteristic curve analysis, the best cut-off value of LA expansion index was < 100%, with an area under the curve (AUC) of 0.86, sensitivity of 80%, and specificity of 74%. LAEF < 30% (AUC 0.76, sensitivity 67%, specificity 70%) and LA emptying fraction < 50% (AUC 0.80, sensitivity 72%, specificity 71%) were also useful but performed less well. Conclusions: Compared with other LA functional parameters, LA expansion index can well represent age-related diastolic dysfunction. ? 2020, Republic of China Society of Cardiology. All rights reserved.
Subjects
Age-related diastolic dysfunction; Left atrial ejection fraction; Left atrial emptying fraction; Left atrial expansion index
SDGs
Other Subjects
adult; age; aged; area under the curve; arterial stiffness; Article; atrial fibrillation; body surface; cardiovascular parameters; cardiovascular risk; CHA2DS2-VASc score; controlled study; coronary artery disease; diagnostic test accuracy study; diastolic blood pressure; diastolic dysfunction; Doppler echocardiography; echocardiography; electrocardiography; epicardial fat; female; forced expiratory volume; heart atrium function; heart atrium septum defect; heart ejection fraction; heart function; heart left atrium; heart left ventricle ejection fraction; heart left ventricle hypertrophy; heart left ventricle mass; heart rate; heart ventricle hypertrophy; hospitalization; human; hypertrophic cardiomyopathy; image quality; left ventricular diastolic dysfunction; major clinical study; male; mitral valve stenosis; New York Heart Association class; peak expiratory flow; prospective study; receiver operating characteristic; reference value; sensitivity and specificity; sinus rhythm; systolic blood pressure; Taiwanese; tissue Doppler imaging; transthoracic echocardiography; two dimensional speckle tracking echocardiography; tympanometry
Type
journal article