Hawthorn: Potential roles in cardiovascular disease
Journal
American Journal of Chinese Medicine
Journal Volume
33
Journal Issue
1
Pages
1-10
Date Issued
2005
Author(s)
Abstract
Hawthorn (Crataegus) may play a role in the prevention and treatment of cardiovascular diseases such as hypertension, hyperlipidemia, and in particular, congestive heart failure. Evidence is accumulating that hawthorn may induce anti-ischemia/reperfusion-injury, anti-arrhythmic, hypolipidemic and hypotensive effects. These beneficial effects may in part be due to the presence of antioxidant flavonoid components. While a number of studies have been performed to evaluate the clinical efficacy of hawthorn, an international, multi-center, prospective clinical study including a large number of New York Heart Association (NYHA) class II/III heart failure patients is ongoing to test hawthorn's long-term therapeutic effects. Further clinical trials as well as pharmacokinetic and mechanistic studies are needed to explore and confirm its effectiveness, safety and pharmacological mechanism. ? 2005 World Scientific Publishing Company.
SDGs
Other Subjects
antioxidant; Crataegus extract; flavonoid; magnesium; placebo; wr 1442; agitation; angina pectoris; antiarrhythmic activity; antihypertensive activity; article; cardiovascular disease; clinical trial; congestive heart failure; Crataegus; dizziness; drug efficacy; drug mechanism; drug safety; drug tolerability; gastrointestinal symptom; headache; heart muscle ischemia; heart palpitation; heart protection; human; hypertension; ischemic heart disease; nonhuman; rash; reperfusion injury; side effect; somnolence; sweating; vertigo; Cardiovascular Diseases; Crataegus; Humans; Medicine, Chinese Traditional; Phytotherapy; Plant Preparations
Type
journal article