https://scholars.lib.ntu.edu.tw/handle/123456789/532338
標題: | Cognitive-Behavioral Therapy for Sleep Disturbance in Patients Undergoing Peritoneal Dialysis: A Pilot Randomized Controlled Trial | 作者: | Chen H.-Y. CHIH-KANG CHIANG Wang H.-H. KUAN-YU HUNG Lee Y.-J. Peng Y.-S. KWAN-DUN WU TUN-JUN TSAI |
公開日期: | 2008 | 卷: | 52 | 期: | 2 | 起(迄)頁: | 314-323 | 來源出版物: | American Journal of Kidney Diseases | 摘要: | Background: Greater than 50% of dialysis patients experience sleep disturbances. Cognitive-behavioral therapy (CBT) is effective for treating chronic insomnia, but its effectiveness has never been reported in peritoneal dialysis (PD) patients and its association with cytokines is unknown. We investigated the effectiveness of CBT in PD patients by assessing changes in sleep quality and inflammatory cytokines. Study Design: Randomized control study with parallel-group design. Setting & Participants: 24 PD patients with insomnia in a tertiary medical center without active medical and psychiatric illness were enrolled. Intervention: The intervention group (N = 13) received CBT from a psychiatrist for 4 weeks and sleep hygiene education, whereas the control group (N = 11) received only sleep hygiene education. Outcomes & Measurements: Primary outcomes were changes in the Pittsburgh Sleep Quality Index and Fatigue Severity Scale scores, and secondary outcomes were changes in serum interleukin 6 (IL-6), IL-1β, IL-18, and tumor necrosis factor α levels during the 4-week trial. Results: Median percentages of change in global Pittsburgh Sleep Quality Index scores were -14.3 (interquartile range, -35.7 to - 6.3) and -1.7 (interquartile range, -7.6 to 7.8) in the intervention and control groups, respectively (P = 0.3). Median percentages of change in global Fatigue Severity Scale scores were -12.1 (interquartile range, -59.8 to -1.5) and -10.5 (interquartile range, -14.3 to 30.4) in the intervention and control groups, respectively (P = 0.04). Serum IL-1β level decreased in the intervention group, but increased in the control group (P = 0.04). There were no significant differences in changes in other cytokines. Limitations: This study had a small number of participants and short observation period, and some participants concurrently used hypnotics. Conclusions: CBT may be effective for improving the quality of sleep and decreasing fatigue and inflammatory cytokine levels. CBT can be an effective nonpharmacological therapy for PD patients with sleep disturbances. ? 2008 National Kidney Foundation, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-47349115810&doi=10.1053%2fj.ajkd.2008.03.012&partnerID=40&md5=05c4be685e30d26711a1358025371e1d https://scholars.lib.ntu.edu.tw/handle/123456789/532338 |
ISSN: | 0272-6386 | DOI: | 10.1053/j.ajkd.2008.03.012 | SDG/關鍵字: | cytokine; interleukin 18 binding protein; interleukin 1beta; interleukin 6; tumor necrosis factor alpha; adult; article; behavior therapy; clinical article; clinical trial; controlled clinical trial; controlled study; cytokine release; education; fatigue; female; health center; human; insomnia; male; mental disease; outcome assessment; peritoneal dialysis; psychiatrist; randomized controlled trial; rating scale; scoring system; sleep disorder; Cognitive Therapy; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis; Pilot Projects; Prospective Studies; Sleep; Sleep Disorders; Time Factors; Treatment Outcome |
顯示於: | 醫學系 |
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