https://scholars.lib.ntu.edu.tw/handle/123456789/532744
標題: | High incidences of invasive fungal infections in acute myeloid leukemia patients receiving induction chemotherapy without systemic antifungal prophylaxis: A prospective observational study in Taiwan | 作者: | JIH-LUH TANG HSIANG-CHI KUNG Lei W.-C. MING YAO UN-IN WU SZU-CHUN HSU Lin C.-T. Li C.-C. SHANG-JU WU HSIN-AN HOU WEN-CHIEN CHOU SHANG-YI HUANG WOEI TSAY YAO-CHANG CHEN YEE-CHUN CHEN SHAN-CHWEN CHANG BOR-SHENG KO HWEI-FANG TIEN |
公開日期: | 2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 6 | 起(迄)頁: | e0128410 | 來源出版物: | PLoS ONE | 摘要: | Invasive fungal infections (IFIs) is an important complication for acute myeloid leukemia (AML) patients receiving induction chemotherapy. However, the epidemiological information is not clear in Southeastern Asia, an area of potential high incidences of IFIs. To clarify it, we enrolled 298 non-M3 adult AML patients receiving induction chemotherapy without systemic anti-fungal prophylaxis from Jan 2004 to Dec 2009, when we applied a prospective diagnostic and treatment algorithm for IFIs. Their demographic parameters, IFI characters, and treatment outcome were collected for analysis. The median age of these patients was 51 years. Standard induction chemotherapy was used for 246 (82.6%) patients, and 66.8% of patients achieved complete remission (CR) or partial remission. The incidence of all-category IFIs was 34.6% (5.7% proven IFIs, 5.0% probable IFIs and 23.8% possible IFIs). Candida tropicalis was the leading pathogen among yeast, and lower respiratory tract was the most common site for IFIs (75.4%, 80/106). Standard induction chemotherapy and failure to CR were identified as risk factors for IFIs. The presence of IFI in induction independently predicted worse survival (hazard ratio 1.536 (1.100-2.141), p value = 0.012). Even in those who survived from the initial IFI insults after 3 months, the presence of IFIs in induction still predicted a poor long-term survival. This study confirms high incidences of IFIs in Southeastern Asia, and illustrates potential risk factors; poor short-term and long-term outcomes are also demonstrated. This epidemiological information will provide useful perspectives for anti-fungal prophylaxis and treatment for AML patients during induction, so that best chances of cure and survival can be provided. ? 2015 Tang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936804320&doi=10.1371%2fjournal.pone.0128410&partnerID=40&md5=6321014e876ba5be5b54fea3acd6a316 https://scholars.lib.ntu.edu.tw/handle/123456789/532744 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0128410 | SDG/關鍵字: | amphotericin B; caspofungin; cotrimoxazole; cytarabine; echinocandin; fluconazole; idarubicin; nystatin; voriconazole; antifungal agent; acute myeloblastic leukemia; adolescent; adult; aged; Article; bacterial infection; cancer combination chemotherapy; cancer survival; Candida tropicalis; drug treatment failure; female; human; incidence; induction chemotherapy; infection control; infection risk; invasive candidiasis; leukemia remission; lower respiratory tract infection; major clinical study; male; multiple cycle treatment; observational study; prediction; prospective study; systemic mycosis; Taiwan; thrush; treatment outcome; Leukemia, Myeloid, Acute; microbiology; middle aged; Mycoses; pre-exposure prophylaxis; remission; risk factor; very elderly; Candida tropicalis; Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Female; Humans; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Pre-Exposure Prophylaxis; Prospective Studies; Remission Induction; Risk Factors; Taiwan; Treatment Outcome |
顯示於: | 醫學系 |
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