https://scholars.lib.ntu.edu.tw/handle/123456789/533279
標題: | Modelling the effect of vaccination on transmission dynamics of nervous necrosis virus in grouper larvae Epinephelus coioides | 作者: | Lu, T.-H. Chen, C.-Y. Yang, Y.-F. YI-FAN YANG CHUNG-MIN LIAO |
公開日期: | 2020 | 卷: | 43 | 期: | 10 | 起(迄)頁: | 1155-1165 | 來源出版物: | Journal of Fish Diseases | 摘要: | Nervous necrosis virus (NNV) infection in susceptible grouper larvae has been reported to cause high mortalities, leading to great economic losses in aquaculture industry. Although the effects of NNV vaccines on grouper have been broadly investigated, vaccination strategies have not been fully established. To this end, we introduced the parsimonious epidemiological models that explored the assessment of key epidemiological parameters and how they changed when vaccinations showed the effects. We showed that the models capture the published cumulative mortality data accurately. We estimated a basic reproduction number R0?=?2.44 for NNV transmission in grouper larvae without vaccination. To effectively control NNV transmission by vaccination, a model for disease control was also generalized to attain the goals of controlled reproduction number less than 1. Our results indicated that at least 60% of grouper population needed to be immunized for ~75?min. Our data-driven modelling approach that links the transmission dynamics of NNV and vaccination strategies for grouper has the potential to support evidence-based planning and adaptation of integrated control measures. We encourage that the epidemiology-based framework introduced here can be further implemented for establishing effective vaccination and mitigation actions aimed at controlling diseases in fish farming practices. ? 2020 John Wiley & Sons Ltd |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85088580262&partnerID=40&md5=82ade127a2e741040ecd769cda3c3c86 https://scholars.lib.ntu.edu.tw/handle/123456789/533279 |
DOI: | 10.1111/jfd.13225 | SDG/關鍵字: | inactivated vaccine; Nervous necrosis virus vaccine; unclassified drug; virus vaccine; adaptive immunity; Article; basic reproduction number; Betanodavirus; conceptual framework; controlled study; epidemic; Epinephelus coioides; evidence based practice; infection control; innate immunity; larva; mortality; Nervous necrosis virus infection; nonhuman; pisciculture; population dynamics; RNA virus infection; susceptible population; treatment duration; vaccination; virus isolation; virus transmission; animal; aquaculture; bass; fish disease; larva; Nodaviridae; pathogenicity; RNA virus infection; Taiwan; theoretical model; vaccination; veterinary medicine; virology; Animals; Aquaculture; Basic Reproduction Number; Bass; Fish Diseases; Larva; Models, Theoretical; Nodaviridae; RNA Virus Infections; Taiwan; Vaccination |
顯示於: | 數學系 |
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