https://scholars.lib.ntu.edu.tw/handle/123456789/533333
標題: | Adhesive pyramidal thorn patches provide pain relief to athletes | 作者: | Saito, N. Shima, R. Yen, C.-T. Yang, R.-C. Ito, E. Yoshioka, T. CHEN-TUNG YEN |
關鍵字: | Aβ fiber; Merkel cell; oxytocin; pain relief; pyramidal thorn patch | 公開日期: | 2019 | 卷: | 35 | 期: | 4 | 起(迄)頁: | 230-237 | 來源出版物: | Kaohsiung Journal of Medical Sciences | 摘要: | Pain in athletes is ideally treated without systemic medicine. Therefore, complementary and alternative medicine, including patch treatments, is often used. The physiologic mechanisms of pain relief produced by patch treatment, however, are not well elucidated. In the present study, we introduce a pyramidal thorn (PT) patch that we developed, demonstrate the effects of this PT patch for the treatment of various types of pain in 300 subjects, and suggest a physiologic mechanism for the pain relief effects. One treatment with the PT patch effectively relieved pain in almost half the subjects evaluated. Except for pain generated deeply under the skin, such as low-back pain, pain was eliminated within four treatments with the PT patch in almost all of the subjects. Interestingly, the pain-sensing region moved along the nerve fibers after each trial. Further, patches without PT also provided some pain relief. We considered that this effect was due to hair deflection on the skin; that is, adhesion of the PT patch activates Merkel cells directly as well as Merkel cell-neurite complexes around the hair follicles by deflecting the hair follicles, whereas adhesion of a patch without PT only activates the Merkel cell-neurite complexes. In any case, patch adhesion stimulates Aβ fibers to alleviate pain. Finally, we found that the pain threshold is increased by electric stimulation, suggesting that the gentle adhesion of a PT patch would be more effective. To our knowledge, this is the first study to demonstrate physiologically the validity of an adherent patch for pain relief. ? 2019 The Authors. The Kaohsiung Journal of Medical Sciences published by John Wiley & Sons Australia on behalf of Kaohsiung Medical University. |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85063232796&partnerID=40&md5=332a9d26c299a82168ef34302b1e6d90 https://scholars.lib.ntu.edu.tw/handle/123456789/533333 |
DOI: | 10.1002/kjm2.12044 | SDG/關鍵字: | oxytocin; adhesive agent; adult; analgesia; analgesic activity; Article; athlete; comparative study; controlled study; electrostimulation; female; hair follicle; human; Japanese (people); judo; knee pain; low back pain; major clinical study; male; Merkel cell; myalgia; neck pain; nerve fiber; pain measurement; pain threshold; analgesia; athlete; clinical trial; pain; pathophysiology; sport; Adhesives; Adult; Analgesia; Athletes; Electric Stimulation; Female; Humans; Male; Pain; Pain Threshold; Sports |
顯示於: | 生命科學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。