|Title:||Potential Association of IL1B Polymorphism With Iron Deficiency Risk in Childhood Helicobacter pylori Infection||Authors:||Chen S.-T.
|Issue Date:||2018||Publisher:||Lippincott Williams and Wilkins||Journal Volume:||66||Journal Issue:||2||Start page/Pages:||e36-e40||Source:||Journal of Pediatric Gastroenterology and Nutrition||Abstract:||
Objective: Helicobacter pylori infection occurs predominantly in childhood. Host immune response gene polymorphism is reported to affect the susceptibility to H pylori infection and the outcome of H pylori-related gastric cancer. Not all H pylori-infected patients, however, exhibit iron deficiency (ID). The relationship between host genetic polymorphisms and ID mediated by H pylori infection is not well understood. Methods: Subjects (n = 644) from the general population of age 10 to 18 years were divided into 2 groups based on serology testing for anti-H pylori IgG: seropositive study group; and seronegative control group. Five single nucleotide polymorphisms (SNPs) in IL1B (rs1143627 and rs16944), IL8 (rs4073), IL10 (rs1800896), and ABO (rs505922), were genotyped and the iron status of the 2 groups was compared. Results: The seroprevalence rate for H pylori was 10.7% in this study. Infected subjects were significantly older and had lower serum iron levels than uninfected subjects (P = 0.0195 and 0.0059, respectively). Multivariate analysis revealed a significantly higher frequency of the T allele of rs505922 (odds ratio [OR] = 6.128; P < 0.001) and lower frequency of the T allele of rs1143627 (OR = 0.846; P = 0.014) in seropositive subjects. Among 59 seropositive subjects, the T allele frequency of rs1143627 was significantly higher in those with ID (OR = 3.156; P = 0.043), compared with those without ID. Conclusions: ABO (rs505922) and IL1B (rs1143627) may affect H pylori infection susceptibility, and IL1B (rs1143627) may also influence ID risk in infected children. Copyright ? 2017 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
|ISSN:||0277-2116||DOI:||10.1097/MPG.0000000000001687||metadata.dc.subject.other:||immunoglobulin G; interleukin 10; interleukin 1beta; interleukin 8; IL10 protein, human; IL1B protein, human; interleukin 10; interleukin 1beta; interleukin 8; iron; adolescent; adult; allele; Article; blood biochemistry; case control study; child; childhood disease; controlled study; female; gene frequency; genotype; Helicobacter infection; human; infection risk; iron blood level; iron deficiency; major clinical study; male; priority journal; serology; seroprevalence; single nucleotide polymorphism; blood; blood group ABO system; complication; genetic predisposition; genetics; Helicobacter infection; Helicobacter pylori; immunology; iron deficiency anemia; seroepidemiology; single nucleotide polymorphism; Taiwan; ABO Blood-Group System; Adolescent; Anemia, Iron-Deficiency; Case-Control Studies; Child; Female; Genetic Predisposition to Disease; Genotype; Helicobacter Infections; Helicobacter pylori; Humans; Interleukin-10; Interleukin-1beta; Interleukin-8; Iron; Male; Polymorphism, Single Nucleotide; Seroepidemiologic Studies; Taiwan
|Appears in Collections:||醫學系|
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