https://scholars.lib.ntu.edu.tw/handle/123456789/534164
標題: | Risk of hyperbilirubinemia in breast-fed infants | 作者: | Chang P.-F. Lin Y.-C. Liu K. Yeh S.-J. YEN-HSUAN NI |
公開日期: | 2011 | 卷: | 159 | 期: | 4 | 起(迄)頁: | 561-565 | 來源出版物: | Journal of Pediatrics | 摘要: | Objective: To investigate the risk factors for hyperbilirubinemia in infants who are exclusively breast-fed. Study design: A prospective study was conducted to investigate the effects of birth body weight, sex, mode of delivery, glucose-6-phosphate dehydrogenase (G6PD) deficiency, variant UDP-glucuronosyltransferase 1A1 (UGT1A1) gene, and hepatic solute carrier organic anion transporter 1B1 (SLCO1B1) gene on hyperbilirubinemia in neonates who were breast-fed. Hyperbilirubinemia was diagnosed when a full term neonate had a bilirubin level ≧15.0 mg/dL (256.5 μM) in serum at 3 days old. The polymerase chain reaction-restriction fragment length polymorphism method was used as a means of detecting the known variant sites in the UGT1A1 and SLCO1B1 gene. Results: Of 252 infants born at term who were exclusively breast-fed, 59 (23.4%) had hyperbilirubinemia. The significant risk factors were a variant nucleotide 211 in UGT1A1 (2.48; 95% CI, 1.29 to 4.76; P =.006), G6PD deficiency (12.24; 95% CI, 1.08 to 138.62; P <.05), and vaginal delivery (3.55; 95% CI, 1.64 to 7.66; P <.001). Conclusion: Breast-fed neonates who are 211 variants in the UGT1A1, G6PD deficiency, and vaginal delivery are at high-risk for hyperbilirubinemia. ? 2011 Mosby Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052790858&doi=10.1016%2fj.jpeds.2011.03.042&partnerID=40&md5=6e39d49eed1005f6183b002829bb64be https://scholars.lib.ntu.edu.tw/handle/123456789/534164 |
ISSN: | 0022-3476 | DOI: | 10.1016/j.jpeds.2011.03.042 | SDG/關鍵字: | bilirubin; glucuronosyltransferase 1A1; organic anion transporter 1; organic anion transporter 1b1; unclassified drug; anion transport; article; asphyxia; bacterial gene; bilirubin blood level; birth weight; blood group ABO incompatibility; breast milk; comparative study; controlled study; DNA isolation; DNA polymorphism; female; gestational age; glucose 6 phosphate dehydrogenase deficiency; hemolytic anemia; heredity; human; hyperbilirubinemia; hypothyroidism; hypoxia; infant; infant disease; liver dysfunction; major clinical study; male; polymerase chain reaction; practice guideline; priority journal; prospective study; restriction fragment length polymorphism; risk factor; tandem mass spectrometry; vaginal delivery; Breast Feeding; Case-Control Studies; Delivery, Obstetric; Female; Glucosephosphate Dehydrogenase Deficiency; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Infant; Infant, Newborn; Male; Organic Anion Transporters; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Prospective Studies; Risk Factors |
顯示於: | 醫學系 |
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