Cytomegalovirus-associated immune thrombocytopenic purpura after liver transplantation
Journal
Journal of the Formosan Medical Association
Journal Volume
106
Journal Issue
4
Pages
327-329
Date Issued
2007
Author(s)
Abstract
Immune thrombocytopenic purpura (ITP) is a rare complication after liver transplantation. Infection with cytomegalovirus (CMV) is a frequent complication of organ transplantation and may induce autoimmune diseases, such as ITP. We report a case of ITP after primary CMV infection in a 3-year-old boy recipient of living-related orthotopic liver transplantation (OLT). The ITP developed 2 years after OLT in this patient who had received tacrolimus as an immunosuppressive agent, with nadir platelet counts of 5000/mm3 in 2 weeks. The patient was treated with two courses of intravenous gamma globulin (1 g/kg/day for 2 days) and subsequent oral prednisolone (1.3 mg/kg/day for 2 weeks). He recovered from thrombocytopenia 4 weeks later. An inadequate immunosuppression, as evident by the low serum tacrolimus level (5.8 ng/ mL before the episode of ITP) in this patient, may allow the development of ITP after CMV infection. ? 2007 Elsevier & Formosan Medical Association.
SDGs
Other Subjects
immunoglobulin; prednisolone; steroid; tacrolimus; antibody blood level; article; blood examination; case report; child; cytomegalovirus infection; drug blood level; graft rejection; human; liver transplantation; living donor; male; orthotopic transplantation; repeated drug dose; serology; thrombocyte count; thrombocytopenia; thrombocytopenic purpura; treatment duration; treatment outcome
Publisher
Scientific Communications International Ltd
Type
journal article