Predictors for vancomycin resistant Enterococcus faecium transforming from colonization to infection: A case control study
Journal
Antimicrobial Resistance and Infection Control
Journal Volume
8
Journal Issue
1
Pages
196
Date Issued
2019
Abstract
Background: (VREfm) colonizers, especially characterized by concordant pulsotypes (CP) of paired colonization and infection-related isolates. Methods: This case-control study was conducted at a teaching hospital between 2011 and 2014. Targeted patients received active surveillance culture for VREfm by anal swabs at admission. Cases were those who developed VREfm infection within 180 days after colonization of VREfm. Controls were those colonized with VREfm without subsequent VREfm infection. CP were defined by similarities ≥86.7% using pulsed-field gel electrophoresis between paired colonization and infection-related isolates. Results: ≤ 0.01). Fifty-six (57.7%) of case patients belonged to the CP group, which were associated with ICU admission (aOR, 3.74; 95% CI, 1.38-10.13), and infection developing within 30 days after colonization (aOR, 3.34; 95% CI, 1.25-8.91). Conclusions: Among VREfm colonizers, being admitted to ICU and receiving CVC or broad spectrum cephalosporins, were the risk factors for subsequent infections. These findings highlight the importance of conducting more strict infection control measures on specific groups of VREfm colonizers.
SDGs
Publisher
BioMed Central Ltd.
Type
journal article