https://scholars.lib.ntu.edu.tw/handle/123456789/535273
標題: | Identifying a targeted population at high risk for infections after liver transplantation in the MELD era | 作者: | HSIN-YUN SUN Cacciarelli T.V. Singh N. |
公開日期: | 2011 | 卷: | 25 | 期: | 3 | 起(迄)頁: | 420-425 | 來源出版物: | Clinical Transplantation | 摘要: | Impact of model for end-stage liver disease (MELD) scoring system on post-transplant infections and associated risk factors are unknown. Infections <90d post-transplant were assessed in 277 consecutive liver transplant recipients from 1999 to 2008. "High-risk" factors for infections were pre-defined as MELD score >30, ICU stay >48h prior to transplant, intraoperative transfusion ?15 units, retransplantation, post-transplant dialysis, or reoperation. Of the 240 recipients in the MELD era (2002-2008), 48.5% had any high-risk factor. The OR for infection was 1.69, 2.00, 18.00, and 4.50 in recipients with any 1, 2, 3, and ?4 high-risk factors, respectively (χ2 for trend, p<0.001). In logistic regression model, recipient age (OR 1.12, p<0.05) and any high-risk factor (OR 2.42, p<0.05) were associated with infections. Compared with 37 pre-MELD recipients, the overall infections and mortality at 12months did not differ in the two eras. In Cox regression model, recipient age (OR 1.09, p<0.05) and any high-risk factor (OR 2.42, p<0.05) remained associated with infections. The overall frequency of infections did not increase in the MELD era. Pre-defined risk factors accurately predicted the risk of infections in these patients. ? 2010 John Wiley & Sons A/S. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79551492924&doi=10.1111%2fj.1399-0012.2010.01262.x&partnerID=40&md5=653e562f5c041838ffb66cfb5b70f37c https://scholars.lib.ntu.edu.tw/handle/123456789/535273 |
ISSN: | 0902-0063 | DOI: | 10.1111/j.1399-0012.2010.01262.x | SDG/關鍵字: | adult; article; blood transfusion; controlled study; dialysis; female; graft recipient; high risk population; human; liver graft; liver transplantation; major clinical study; male; mortality; postoperative infection; priority journal; proportional hazards model; reoperation; retransplantation; risk factor; scoring system; End Stage Liver Disease; Female; Health Services Needs and Demand; Humans; Immunocompromised Host; Infection; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Prognosis; Risk Factors; Survival Rate; United States |
顯示於: | 醫學系 |
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