https://scholars.lib.ntu.edu.tw/handle/123456789/535374
標題: | Performance of fracture risk assessment tool in HIV-positive male individuals aged ≥45 years on suppressive antiretroviral therapy | 作者: | Tsai M.-S. Zhang J.-Y. HSIN-YUN SUN Liu W.-C. Wu P.-Y. Yang C.-J. CHIEN-CHING HUNG |
公開日期: | 2019 | 出版社: | John Wiley and Sons Inc. | 卷: | 22 | 期: | 8 | 起(迄)頁: | e25383 | 來源出版物: | Journal of the International AIDS Society | 摘要: | Introduction: An age-specific evaluation and management algorithm for reduced bone mineral density (BMD) is suggested for HIV-positive patients without major risk factors. Whether combination of BMD and the Fracture Risk Assessment Tool (FRAX) may detect more individuals for therapeutic interventions remains unclear. We aimed to determine the prevalence of middle-aged or older HIV-positive males fitting the criteria of therapeutic interventions with different approaches. Methods: From July 2016 to February 2018, HIV-positive male patients aged ?45?years receiving suppressive antiretroviral therapy were recruited in a cross-sectional study, at two designated hospitals for HIV care in northern Taiwan. Patients with malignancy, AIDS, pre-existing bone disease or immobilization were excluded. Information on clinical and demographic characteristics, FRAX questionnaire, activity questionnaire, BMD and serum 25(OH)D was obtained. FRAX scores combined with BMD (FRAX/BMD) and without BMD (FRAX) were calculated. The data were analysed on the basis of major risk factors for fragility fracture and age stratification, FRAX score and BMD results respectively. Results: We enrolled 330 patients with a mean age of 51.6?years and CD4 610?cells/μL, in whom 98.1% (n?=?324) underwent BMD assessment of one site or more. By FRAX, 6.7% (n?=?22) reached treatment thresholds (10-year risk of major osteoporotic fracture ?20% and/or hip fracture ?3%). The prevalence of osteopenia (?2.5 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071465891&doi=10.1002%2fjia2.25383&partnerID=40&md5=290414bad5570924a31d7acc34c885a1 https://scholars.lib.ntu.edu.tw/handle/123456789/535374 |
ISSN: | 1758-2652 | DOI: | 10.1002/jia2.25383 | SDG/關鍵字: | 25 hydroxyvitamin D; anti human immunodeficiency virus agent; glucocorticoid; proteinase inhibitor; ritonavir; tenofovir disoproxil; anti human immunodeficiency virus agent; adult; antiretroviral therapy; Article; bone density; bone disease; CD4 lymphocyte count; cross-sectional study; demography; fracture; fragility fracture; hip fracture; human; Human immunodeficiency virus infection; immobilization; low risk population; lumbar spine; major clinical study; male; middle aged; osteopenia; osteoporosis; physical activity; priority journal; risk assessment; sensitivity and specificity; vitamin blood level; algorithm; complication; fracture; fragility fracture; hip fracture; Human immunodeficiency virus infection; osteoporosis; prevalence; questionnaire; risk factor; Taiwan; Adult; Algorithms; Anti-HIV Agents; Bone Density; Cross-Sectional Studies; Fractures, Bone; Hip Fractures; HIV Seropositivity; Humans; Male; Middle Aged; Osteoporosis; Osteoporotic Fractures; Prevalence; Risk Factors; Surveys and Questionnaires; Taiwan |
顯示於: | 醫學系 |
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