https://scholars.lib.ntu.edu.tw/handle/123456789/535388
標題: | Incidence of acute hepatitis A among HIV-positive patients during an outbreak among MSM in Taiwan: Impact of HAV vaccination | 作者: | Chen G.-J. KUAN-YIN LIN HSIN-YUN SUN WANG-HUEI SHENG SZU-MIN HSIEH YI-CHIA HUANG ARISTINE CHENG Liu W.-C. CHIEN-CHING HUNG SHAN-CHWEN CHANG |
公開日期: | 2018 | 出版社: | Blackwell Publishing Ltd | 卷: | 38 | 期: | 4 | 起(迄)頁: | 594-601 | 來源出版物: | Liver International | 摘要: | Background: An unprecedented outbreak of acute hepatitis A has occurred among MSM in Taiwan since June 2015. We aimed to describe the seroepidemiology of HAV infection and to investigate the relationship between HAV vaccination and the incidence of acute hepatitis A among HIV-positive patients at the largest designated hospital for HIV care during the outbreak. Methods: Between 2012 and 2016, the HAV serostatus, vaccination history and clinical characteristics of HIV-positive patients were retrospectively reviewed. A case-control study was performed to identify the factors associated with acute hepatitis A. The trends of HAV vaccination rate and incidence of acute hepatitis A among HAV-seronegative patients were examined during the outbreak. Results: During the 4.5-year period, 2088 HIV-positive patients with a mean age of 37.7?years and 90.2% being MSM were included. The overall HAV seroprevalence was 34.3%, which was significantly higher in older and non-MSM patients. The estimated incidence rate of acute hepatitis A was 52.6 cases per 1000 person-years of follow-up during the outbreak. The associated factors with acquiring acute hepatitis A were recent syphilis and having not received HAV vaccines. The HAV vaccination rate during the outbreak increased from 4.7% to 70.6% and the incidence rate of acute hepatitis A declined when up to 65% of the patients were immunized or tested positive for HAV. Conclusions: The seroprevalence of HAV infection was low in the younger HIV-positive individuals. Prevention of acute hepatitis A was achieved among HIV-positive, HAV-seronegative patients through HAV vaccination and increased herd immunity during the ongoing outbreak. ? 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020117662&doi=10.1111%2fliv.13468&partnerID=40&md5=a374a0894b0995a2cd1d4ff8faa343a4 https://scholars.lib.ntu.edu.tw/handle/123456789/535388 |
ISSN: | 1478-3223 | DOI: | 10.1111/liv.13468 | SDG/關鍵字: | hepatitis A vaccine; hepatitis A vaccine; acute hepatitis A; adult; Article; case control study; cohort analysis; controlled study; epidemic; follow up; health impact assessment; herd immunity; human; Human immunodeficiency virus infection; incidence; major clinical study; male; men who have sex with men; retrospective study; seroepidemiology; seroprevalence; syphilis; Taiwan; vaccination; acute disease; complication; female; hepatitis A; Human hepatitis A virus; Human immunodeficiency virus infection; male homosexuality; middle aged; multivariate analysis; statistical model; statistics and numerical data; vaccination; Acute Disease; Adult; Case-Control Studies; Disease Outbreaks; Female; Hepatitis A; Hepatitis A Vaccines; Hepatitis A Virus, Human; HIV Infections; Homosexuality, Male; Humans; Incidence; Logistic Models; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Seroepidemiologic Studies; Syphilis; Taiwan; Vaccination |
顯示於: | 醫學系 |
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