|Title:||Echinocandins in invasive candidiasis||Authors:||Simon J.
|Issue Date:||2013||Publisher:||Blackwell Publishing Ltd||Journal Volume:||56||Journal Issue:||6||Start page/Pages:||601-609||Source:||Mycoses||Abstract:||
We summarise a recent meeting, sponsored by Pfizer Inc., where experts in Asia shared their clinical experience in managing IC. The echinocandins have demonstrated good activity against non-albicans infections and also azole-resistant strains, both preclinically and in recent clinical trials. As well as proving efficacious, echinocandins have a favourable safety profile and are well tolerated, including among inpatient subpopulations, such as transplant recipients and those with renal or hepatic dysfunction. In addition the echinocandins generally have minimal drug-drug interactions, unlike the oral azoles, which have multiple effects on cytochrome P450-mediated drug metabolism. Echinocandins are characterised by a good safety profile, few drug-drug interactions and good susceptibilities. With the increase in potentially azole-resistant non-albicans infections, echinocandins may become the first-line treatment of choice for many patients. ? 2013 Blackwell Verlag GmbH.
|ISSN:||0933-7407||DOI:||10.1111/myc.12085||SDG/Keyword:||amphotericin B; anidulafungin; caspofungin; cytochrome P450; fluconazole; host factor; micafungin; abdominal pain; antifungal activity; antifungal susceptibility; area under the curve; Candida albicans; candidemia; critically ill patient; diarrhea; disease predisposition; drug clearance; drug efficacy; drug protein binding; drug safety; fever; fungus growth; graft recipient; hematopoietic stem cell transplantation; human; iatrogenic disease; in vitro study; infection risk; invasive candidiasis; maximum plasma concentration; minimum inhibitory concentration; nausea; phlebitis; priority journal; review; time to maximum plasma concentration; vomiting; candidaemia; critically ill; Echinocandins; Antifungal Agents; Candidiasis, Invasive; Echinocandins; Humans; World Health
|Appears in Collections:||醫學系|
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