https://scholars.lib.ntu.edu.tw/handle/123456789/535436
標題: | Rhino-orbital-cerebral zygomycosis in solid organ transplant recipients | 作者: | HSIN-YUN SUN Forrest G. Gupta K.L. Aguado J.M. Lortholary O. Julia M.B. Safdar N. Patel R. Kusne S. Singh N. |
公開日期: | 2010 | 卷: | 90 | 期: | 1 | 起(迄)頁: | 85-92 | 來源出版物: | Transplantation | 摘要: | Background: Rhino-orbital-cerebral disease is a significant manifestation of zygomycosis in solid organ transplant (SOT) recipients. However, its characteristics and outcome are not well addressed. Methods: SOT recipients with zygomycosis as per the European Organization for Research and Treatment in Cancer and the Mycoses Study Group criteria in a cohort study at our centers published previously and those identified with a PubMed search from the 1950s to November 2009 were studied. Patients with mycosis involving the sinuses, orbits, or central nervous system (CNS) were included. Results: Patients comprised a total of 90 SOT recipients with rhino-orbital-cerebral zygomycosis, including 13 in our cohort and 77 in the literature. CNS disease occurred in 57% (51 of 90). Overall mortality was 52.3% (46 of 88), and the mortality in patients with CNS disease was 73.5% (36 of 49). In logistic regression analysis, older age (odds ratio [OR] 1.12, 95% confidence interval [CI] 1.04-1.21, P=0.002) was associated with a higher mortality rate, whereas lipid formulations of amphotericin B compared with amphotericin B deoxycholate (OR 0.09, 95% CI 0.02-0.50, P=0.006) and surgery (OR 0.12, 95% CI 0.01-0.94, P=0.043) were independently associated with an improved survival even when controlled for CNS involvement and the era of diagnosis of disease. ConclusionS: Rhino-orbital-cerebral zygomycosis, particularly CNS disease, is associated with substantial mortality rate in SOT recipients. Older age is a significant risk factor for mortality, whereas lipid formulations of amphotericin B and surgery improved outcomes. Copyright ? 2010 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954611098&doi=10.1097%2fTP.0b013e3181dde8fc&partnerID=40&md5=02a93b6755f084d620d34bcffe4ef0e4 https://scholars.lib.ntu.edu.tw/handle/123456789/535436 |
ISSN: | 0041-1337 | DOI: | 10.1097/TP.0b013e3181dde8fc | SDG/關鍵字: | amphotericin B deoxycholate; amphotericin B lipid complex; adult; age; aged; article; central nervous system disease; cohort analysis; controlled study; female; graft recipient; human; major clinical study; male; mortality; mucormycosis; organ transplantation; priority journal; rhinoorbital cerebral zygomycosis; risk factor; survival; treatment outcome; Adult; Aged; Amphotericin B; Antifungal Agents; Brain Diseases; Cohort Studies; Debridement; Female; Humans; Kidney Transplantation; Liver Transplantation; Male; Middle Aged; Mycoses; Organ Transplantation; Regression Analysis; Sinusitis; Zygomycosis |
顯示於: | 醫學系 |
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