https://scholars.lib.ntu.edu.tw/handle/123456789/535490
標題: | Successful discontinuation of fluconazole as secondary prophylaxis for cryptococcosis in AIDS patients responding to highly active antiretroviral therapy | 作者: | WANG-HUEI SHENG CHIEN-CHING HUNG Chen M.Y. SZU-MIN HSIEH SHAN-CHWEN CHANG |
公開日期: | 2002 | 出版社: | SAGE Publications Ltd | 卷: | 13 | 期: | 10 | 起(迄)頁: | 702-705 | 來源出版物: | International Journal of STD and AIDS | 摘要: | Seven AIDS patients with disseminated cryptococcosis who had had immune reconstitution following highly active antiretroviral therapy (HAART) had discontinued their secondary antifungal prophylaxis to prevent relapse of Cryptococcus neoformans infection. The median CD4+ count was 236 cells/μL (range, 117-404 cells/μL; mean, 247 cells/μL) and the plasma viral loads were undetectable in five patients at discontinuation of antifungal prophylaxis. No relapse of cryptococcosis was detected in these patients after a median observation duration of nine months (range, 5.5-4.1 months, mean, 14.6 months) following discontinuation. Our data and review of the literature suggest that discontinuation of fluconazole prophylaxis is safe in patients with reconstitution of immunity following initiation of HAART. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036788061&doi=10.1258%2f095646202760326462&partnerID=40&md5=755b5b6f943cce67bad81e6bae8b5ef9 https://scholars.lib.ntu.edu.tw/handle/123456789/535490 |
ISSN: | 0956-4624 | DOI: | 10.1258/095646202760326462 | SDG/關鍵字: | amphotericin B; fluconazole; acquired immune deficiency syndrome; adult; article; clinical article; cryptococcosis; Cryptococcus neoformans; drug withdrawal; female; highly active antiretroviral therapy; human; lymphocyte count; male; priority journal; prophylaxis; relapse; virus load |
顯示於: | 醫學系 |
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