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  4. Immune response of single dose vaccination against 2009 pandemic influenza A (H1N1) in the Taiwanese elderly
 
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Immune response of single dose vaccination against 2009 pandemic influenza A (H1N1) in the Taiwanese elderly

Journal
Vaccine
Journal Volume
28
Journal Issue
38
Pages
6159-6163
Date Issued
2010
Author(s)
Kao T.M.
SZU-MIN HSIEH  
HSIANG-CHI KUNG  
Lee Y.C.
KUO-CHIN HUANG  
LI-MIN HUANG  
Chang F.Y.
Wang N.C.
Liu Y.C.
Lee W.S.
Liu H.E.
Chen C.I.
Chen C.-H.
DOI
10.1016/j.vaccine.2010.07.026
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955661281&doi=10.1016%2fj.vaccine.2010.07.026&partnerID=40&md5=028b9e3692649171c9a04bbc6a88a0a6
https://scholars.lib.ntu.edu.tw/handle/123456789/535569
Abstract
We conducted a multi-center, randomized and laboratory-blinded clinical trial with subgroup analyses, involving adults aged greater than 60 years old (range 61-86 years old), to investigate the immunogenicity and the potential factors affecting the immune response of a monovalent, unadjuvanted, inactivated, split-virus vaccine. A total of 107 subjects were randomized to receive 15 and 30μg of hemagglutinin antigen in a 1:1 ratio. The immunogenicity was detected through hemagglutination inhibition (HAI) test of serum obtained before and 3 weeks after vaccination. By 3 weeks after vaccination, HAI titer ?1:40 was observed in 75.5% and 81.1% of participants receiving 15 and 30μg of hemagglutinin antigen, respectively. Positive seroconversion was observed in 71.7% and 81.1% of recipients of the 15 and the 30μg, respectively. The GMTs increased by a factor of 10.7 and 17.4 in the groups of 15 and 30μg, respectively. This study indicated that one dose of 15μg hemagglutinin antigen without adjuvant induced protective immune response in the majority of elderly. Multivariate logistic regression analyses showed that gender, age and diabetes were statistically significant factors affecting the seroprotection rate (p=0.04, 0.01 and 0.01, respectively) and seroconversion rate (p=0.01, 0.01 and 0.01, respectively). ? 2010 Elsevier Ltd.
SDGs

[SDGs]SDG3

Other Subjects
Influenza virus hemagglutinin; aged; antibody titer; article; body mass; clinical trial; comorbidity; controlled clinical trial; controlled study; diabetes mellitus; dose response; female; hemagglutination inhibition; human; immune response; immunogenicity; influenza A (H1N1); influenza vaccination; Influenza virus A H1N1; major clinical study; male; multicenter study; pandemic; priority journal; randomized controlled trial; seroconversion; Taiwan; Age Factors; Aged; Aged, 80 and over; Antibodies, Viral; Antibody Formation; Diabetes Mellitus; Female; Hemagglutination Inhibition Tests; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Logistic Models; Male; Middle Aged; Multivariate Analysis; Sex Factors; Single-Blind Method; Taiwan
Type
journal article

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