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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/535569
Title: Immune response of single dose vaccination against 2009 pandemic influenza A (H1N1) in the Taiwanese elderly
Authors: Kao T.M.
SZU-MIN HSIEH 
Kung H.C.
Lee Y.C.
KUO-CHIN HUANG 
LI-MIN HUANG 
Chang F.Y.
Wang N.C.
Liu Y.C.
Lee W.S.
Liu H.E.
Chen C.I.
Chen C.-H.
Issue Date: 2010
Journal Volume: 28
Journal Issue: 38
Start page/Pages: 6159-6163
Source: Vaccine
Abstract: 
We conducted a multi-center, randomized and laboratory-blinded clinical trial with subgroup analyses, involving adults aged greater than 60 years old (range 61-86 years old), to investigate the immunogenicity and the potential factors affecting the immune response of a monovalent, unadjuvanted, inactivated, split-virus vaccine. A total of 107 subjects were randomized to receive 15 and 30μg of hemagglutinin antigen in a 1:1 ratio. The immunogenicity was detected through hemagglutination inhibition (HAI) test of serum obtained before and 3 weeks after vaccination. By 3 weeks after vaccination, HAI titer ?1:40 was observed in 75.5% and 81.1% of participants receiving 15 and 30μg of hemagglutinin antigen, respectively. Positive seroconversion was observed in 71.7% and 81.1% of recipients of the 15 and the 30μg, respectively. The GMTs increased by a factor of 10.7 and 17.4 in the groups of 15 and 30μg, respectively. This study indicated that one dose of 15μg hemagglutinin antigen without adjuvant induced protective immune response in the majority of elderly. Multivariate logistic regression analyses showed that gender, age and diabetes were statistically significant factors affecting the seroprotection rate (p=0.04, 0.01 and 0.01, respectively) and seroconversion rate (p=0.01, 0.01 and 0.01, respectively). ? 2010 Elsevier Ltd.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955661281&doi=10.1016%2fj.vaccine.2010.07.026&partnerID=40&md5=028b9e3692649171c9a04bbc6a88a0a6
https://scholars.lib.ntu.edu.tw/handle/123456789/535569
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2010.07.026
SDG/Keyword: Influenza virus hemagglutinin; aged; antibody titer; article; body mass; clinical trial; comorbidity; controlled clinical trial; controlled study; diabetes mellitus; dose response; female; hemagglutination inhibition; human; immune response; immunogenicity; influenza A (H1N1); influenza vaccination; Influenza virus A H1N1; major clinical study; male; multicenter study; pandemic; priority journal; randomized controlled trial; seroconversion; Taiwan; Age Factors; Aged; Aged, 80 and over; Antibodies, Viral; Antibody Formation; Diabetes Mellitus; Female; Hemagglutination Inhibition Tests; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Logistic Models; Male; Middle Aged; Multivariate Analysis; Sex Factors; Single-Blind Method; Taiwan
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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