The use of micro-needle arrays to deliver cells for cellular therapies
Journal
Biomedical Microdevices
Journal Volume
22
Journal Issue
4
Date Issued
2020
Author(s)
Abstract
Cell therapy is used to treat various diseases and to repair injuries. Cell delivery is a crucial process that delivers cells to target sites. Cells must be precisely delivered to a target site and the cells that are delivered must be localized to the target site to repair damaged tissue. For stem cell therapy, the most convenient method of cell delivery involves directly injecting cells into damaged tissue. Other strategies use carriers to transplant stem cells into damaged tissue. These are termed, stem cell delivery systems (SCDSs). Micro-needle arrays are minimally invasive transdermal delivery systems. The devices can pass through the stratum corneum barrier and deliver macromolecules into the skin. They can also access the microcirculation system in the skin. This study fabricates PMMA micro-needle using a two-stage micro-molding method. Cells are seeded on the micro-needle arrays and then transferred into the target tissue. Collagen hydrogel is used as a model biomimetic tissue. Cells are efficiently delivered to regions of interest, collagen hydrogel, by using this system. The delivery rate is about 83.2%. This demonstrates that micro-needle arrays allow very efficient delivery of cells. ? 2020, Springer Science+Business Media, LLC, part of Springer Nature.
SDGs
Other Subjects
Biomimetics; Collagen; Disease control; Hydrogels; Microcirculation; Needles; Stem cells; Tissue; Cellular therapy; Method of cells; Microcirculation systems; Minimally invasive; Regions of interest; Stem cell therapy; Stratum corneum; Transdermal delivery systems; Cytology; collagen; poly(methyl methacrylate); Article; biomimetics; cell therapy; compression; controlled study; HaCat cell line; human; human cell; micromolding; microtechnology; priority journal; target tissue; animal; biological therapy; cytology; devices; drug delivery system; microinjection; needle; stem cell; Animals; Cell- and Tissue-Based Therapy; Drug Delivery Systems; Humans; Microinjections; Needles; Stem Cells
Type
journal article