Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan
Journal
Antimicrobial Agents and Chemotherapy
Journal Volume
57
Journal Issue
8
Pages
4072-4076
Date Issued
2013
Author(s)
Huang T.-W.
Lauderdale T.-L.
Liao T.-L.
Lai J.-F.
Tan M.-C.
Lin A.-C.
Chen Y.-T.
Tsai S.-F.
Abstract
Genetic determinants of a bla(NDM-1)-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a bla(NDM-1) gene in pKOX_NDM1 and two extended-spectrum β-lactamase producers (bla(CTX-M-3) and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrug-resistant bacterial infections and the potential danger of emerging resistant enterobacteria.
Type
journal article