Compassionate use of linezolid for adult taiwanese patients with bone and joint infections
Journal
Chemotherapy
Journal Volume
56
Journal Issue
6
Pages
429-435
Date Issued
2010
Author(s)
Abstract
Background: Compassionate use of linezolid for bone and joint infections has been reported and hematological adverse reactions are a cause for concern. A similar experience in Asian people has not been reported. Methods: Adult cases that received linezolid for bone and joint infections at 3 Taiwanese medical centers from 2002 to 2006 were analyzed. We investigated factors associated with treatment outcome and hematological adverse reactions. Results: Of the 51 cases that received linezolid for more than 3 days, 41 (80.4%) had a favorable outcome and 10 had a failed outcome. Based on univariate analysis, patients with renal/urinary tract diseases, gastrointestinal diseases, higher WBC counts, a higher alanine aminotransferase level, or a higher creatinine level prior to linezolid treatment were significantly associated with a failed outcome. Based on multivariate analysis, underlying gastrointestinal disease was the only significant factor for a failed outcome. Six patients stopped linezolid use due to adverse reactions. A failed outcome was significantly associated with anemia caused by linezolid. Conclusion: Linezolid is an effective salvage agent for bone and joint infections. However, adverse effects, especially hematological reactions, may cause drug discontinuation. Copyright ? 2010 S. Karger AG, Basel.
SDGs
Other Subjects
alanine aminotransferase; cefazolin; ciprofloxacin; cotrimoxazole; creatinine; fusidic acid; gentamicin; linezolid; oxacillin; rifampicin; teicoplanin; vancomycin; adult; aged; anemia; antibiotic therapy; article; bone and joint infections; compassionate use; drug efficacy; drug hypersensitivity; drug treatment failure; drug withdrawal; female; gastrointestinal disease; human; kidney disease; leukocyte count; major clinical study; male; methicillin resistant Staphylococcus aureus infection; monotherapy; patient compliance; priority journal; thrombocytopenia; treatment outcome; treatment refusal; urinary tract disease; Acetamides; Adult; Anti-Infective Agents; Arthritis, Infectious; Compassionate Use Trials; Female; Humans; Male; Osteomyelitis; Oxazolidinones; Retrospective Studies; Staphylococcal Infections; Treatment Outcome
Type
journal article