Safety and efficacy of cefpirome in comparison with ceftazidime in chinese patients with sepsis due to bacterial infections
Journal
Chemotherapy
Journal Volume
46
Journal Issue
5
Pages
371-378
Date Issued
2000
Author(s)
Abstract
Background:The safety and efficacy of cefpirome (CPM), a fourth-generation cephalosporin, has not yet been studied in an Asian population. Methods: Sixty-nine adult Chinese patients with sepsis due to bacterial infections were enrolled in the study and randomly assigned to receive CPM (2 g i.v. every 12 h) or ceftazidime (2 g i.v. every 8 h). Results: Both groups were comparable in terms of demographic, clinical and microbiological features. The causative pathogen was Escherichia coll or Klebsiella pneumoniae in the majority of microbiologically docu-mented cases. The rates of clinical response (94 vs. 94%) and bacteriological response (65 vs. 68%) were similar in both groups. Similar adverse events, including rashes, gastrointestinal upset and asymptomatic elevation of hepatic enzymes, occurred in a minority of patients in both groups. All events were selflimited after discontinuation of the drugs. Conclusion: CPM is as safe and effective as ceftazidime in the treatment of sepsis due to bacterial infections in Chinese patients. Copyright ©2000 S. Karger AG,.
SDGs
Publisher
S. Karger AG
Type
journal article