https://scholars.lib.ntu.edu.tw/handle/123456789/536287
標題: | A multicentre surveillance study on the characteristics, bacterial aetiologies and in vitro antibiotic susceptibilities in patients with acute exacerbations of chronic bronchitis | 作者: | Hui D.S. Ip M. Ling T. SHAN-CHWEN CHANG Liao C.-H. Yoo C.-G. Kim D.-K. Yoon H.-I. Udompanich V. Mogmeud S. Muttalif R. Salleh A.M. Roa C. Mendoza M. Fajardo-Ang C. Soepandi P. Isbaniah F. Burhan E. Sudarmono P. Mangunnegoro H. Liu H.H. |
關鍵字: | Acute exacerbation; Antibiotics; Bacteria; Chronic bronchitis; Sputum bacteriology | 公開日期: | 2011 | 卷: | 16 | 期: | 3 | 起(迄)頁: | 532-539 | 來源出版物: | Respirology | 摘要: | Background and objective: Antimicrobial resistance is a global problem and the prevalence is high in many Asian countries. Methods: A prospective observational study of the prevalence of bacterial pathogens and their antimicrobial susceptibilities in patients with acute exacerbations of chronic bronchitis (AECB) was conducted in Indonesia, Philippines, Korea, Thailand, Malaysia, Taiwan andHong Kong fromAugust 2006 to April 2008. The diagnosis of AECB was based on increased cough andworsening of two of following: dyspnoea, increased sputum volume or purulence. Patients who had taken antibiotics within 72 h of presentation were excluded. All bacterial strains were submitted to a central laboratory for re-identification and antimicrobial susceptibility testing to 16 antimicrobial agents according to Clinical and Laboratory Standards Institute. Results: Four hundred and seven isolates were identified among 447 patients of AECB. The most frequent organisms isolated were Klebsiella pneumoniae and associated species (n = 91 + 17), Haemophilus influenzae (n = 71), Pseudomonas aeruginosa (n = 63), Streptococcus pneumoniae (n = 32), Acinetobacter baumannii (n = 22) andMoraxella catarrhalis (n = 21). According to Clinical and Laboratory Standards Institute susceptibility breakpoints, 85.7% and >90% of these pathogens were susceptible to levofloxacin and cefepime respectively.Other options with overall lower susceptibilities include imipenem, ceftazidime, ceftriaxone and amoxicillin/clavulanate. Conclusions: Gram-negative bacteria including Klebsiella spp., P. aeruginosa and Acinetobacter spp. constitute a large proportion of pathogens identified in patients with AECB in some Asian countries. Surveillance on the local prevalence and antibiotic resistance of these organisms is important in guiding appropriate choice of antimicrobials in the management of AECB. ? 2011 The Authors Respirology ? 2011 Asian Pacific Society of Respirology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953268180&doi=10.1111%2fj.1440-1843.2011.01943.x&partnerID=40&md5=46d7087994263792910109718ee5e38b https://scholars.lib.ntu.edu.tw/handle/123456789/536287 |
ISSN: | 1323-7799 | DOI: | 10.1111/j.1440-1843.2011.01943.x | SDG/關鍵字: | amikacin; amoxicillin plus clavulanic acid; azithromycin; beta 2 adrenergic receptor stimulating agent; cefepime; cefotaxime; ceftazidime; ceftriaxone; cefuroxime; cephalosporin; ciprofloxacin; corticosteroid; cotrimoxazole; dexamethasone; hydrocortisone; imipenem; levofloxacin; macrolide; moxifloxacin; penicillin G; piperacillin plus tazobactam; prednisolone; quinoline derived antiinfective agent; Acinetobacter baumannii; adult; aged; antibiotic resistance; antibiotic therapy; article; bacterial strain; bacterium identification; chronic bronchitis; chronic bronchitis acute exacerbation; corticosteroid therapy; coughing; disease exacerbation; dyspnea; female; Haemophilus influenzae; Hong Kong; human; Indonesia; Klebsiella pneumoniae; major clinical study; Malaysia; male; microbial sensitivity test; minimum inhibitory concentration; Moraxella catarrhalis; observational study; Philippines; priority journal; prospective study; Pseudomonas aeruginosa; South Korea; sputum; Streptococcus pneumoniae; Taiwan; Thailand; Acute Disease; Aged; Aged, 80 and over; Anti-Bacterial Agents; Asia; Bronchitis, Chronic; Comorbidity; Disease Progression; Drug Resistance, Bacterial; Female; Gram-Negative Bacteria; Humans; Male; Middle Aged; Prospective Studies; Smoking; Sputum |
顯示於: | 醫學系 |
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