https://scholars.lib.ntu.edu.tw/handle/123456789/536480
標題: | Proteinuria and reduced estimated glomerular filtration rate independently predict risk for acute myocardial infarction: Findings from a population-based study in Keelung, Taiwan | 作者: | Chang S.-H. CHIA-TI TSAI Yen A.M.-F. Lei M.-H. Chen, Tony Hsiu Hsi Tseng C.-D. |
關鍵字: | Acute myocardial infarction; Estimated glomerular filtration rate; Proteinuria | 公開日期: | 2015 | 出版社: | Republic of China Society of Cardiology | 卷: | 31 | 期: | 2 | 起(迄)頁: | 106-112 | 來源出版物: | Acta Cardiologica Sinica | 摘要: | Background: The aim of this study was to evaluate the independent roles of proteinuria and reduced estimated glomerular filtration rate (GFR) in the development of acute myocardial infarction in a northern Taiwanese population. Methods: We conducted a community-based prospective cohort study in Keelung, the northernmost county of Taiwan. A total of 63,129 subjects (63% women) ? 20 years of age who had no history of coronary heart disease were recruited and followed-up. Univariate and multivariate proportional hazards regression analysis was performed to assess the association between proteinuria and estimated GFR and the risk of acute myocardial infarction. Results: There were 305 new cases of acute myocardial infarction (114 women and 191 men) documented during a four-year follow-up period. After adjustment of potential confounding covariates, heavier proteinuria (dipstick urinalysis reading 3+) and estimated GFR of less than 60 ml/min/1.73 m2 independently predicted increased risk of developing acute myocardial infarction. The adjusted hazard ratio (aHR) of heavier proteinuria for occurrence of acute myocardial infarction was 1.85 [95% confidence intervals (CI), 1.17-2.91, p < 0.01] (vs. the reference group: negative dipstick proteinuria). The aHR of estimated GFR of 30-59 ml/min/1.73 m2 for occurrence of acute myocardial infarction was 2.4 (95% CI, 1.31-4.38, p < 0.01) (vs. the reference group: estimated GFR ? 90 ml/min/1.73 m2), and that of estimated GFR of 15-29 ml/min/1.73 m2 was 5.26 (95% CI, 2.26-12.26, p < 0.01). Conclusions: We demonstrated that both heavier proteinuria and lower estimated GFR are significant independent predictors of developing future acute myocardial infarction in a northern Taiwanese population. ? 2015, Republic of China Society of Cardiology. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925351941&doi=10.6515%2fACS20141201A&partnerID=40&md5=b1eb2b4166b29f427dab168b9a7bfb89 https://scholars.lib.ntu.edu.tw/handle/123456789/536480 |
ISSN: | 1011-6842 | DOI: | 10.6515/ACS20141201A | SDG/關鍵字: | acute heart infarction; adult; age distribution; aged; Article; cardiovascular risk; cohort analysis; female; follow up; glomerular dysfunction; glomerulus filtration rate; human; hypercholesterolemia; hypertension; major clinical study; male; middle aged; population; predictive value; prospective study; proteinuria; risk assessment; sex difference; Taiwan; Taiwanese; urinalysis; young adult |
顯示於: | 醫學系 |
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