Cardiac mechanics and ventricular twist by three-dimensional strain analysis in relation to B-type natriuretic peptide as a clinical prognosticator for heart failure patients
Journal
PLoS ONE
Journal Volume
9
Journal Issue
12
Date Issued
2014
Author(s)
Lai Y.-H.
Yen C.-H.
Bulwer B.E.
Hung T.-C.
Hou C.J.-Y.
Kuo J.-Y.
Hung C.-L.
Yeh H.-I.
Abstract
Background: Three dimensional (3D) echocardiography-derived measurements of myocardial deformation and twist have recently advanced as novel clinical tools. However, with the exception of left ventricular ejection fraction and mass quantifications in hypertension and heart failure populations, the prognostic value of such imaging techniques remains largely unexplored. Methods: We studied 200 subjects (mean age: 60.2±16 years, 54% female, female n=107) with known hypertension (n=51), diastolic heart failure (n=61), or systolic heart failure (n=30), recruited from heart failure outpatient clinics. Fiftyeight healthy volunteers were used as a control group. All participants underwent 3D-based myocardial deformation and twist analysis (Artida, Toshiba Medical Systems, Tokyo, Japan). We further investigated associations between these measures and brain natriuretic peptide levels and clinical outcomes. Results: The global 3D strain measurements of the healthy, hypertension, diastolic heart failure, and systolic heart failure groups were 28.03%, 24.43%, 19.70%, and 11.95%, respectively (all p<0.001). Global twist measurements were estimated to be 9.49°, 9.77°, 8.32°, and 4.56°, respectively. We observed significant differences regarding 3D-derived longitudinal, radial, and global 3D strains between the different disease categories (p<0.05), even when age, gender, BMI and heart rate were matched. In addition, 3D-derived longitudinal, circumferential, and 3D strains were all highly correlated with brain natriuretic peptide levels (p<0.001). At a mean 567.7 days follow-up (25th-75th IQR: 197-909 days), poorer 3D-derived longitudinal, radial, and global 3D strain measurements remained independently associated with a higher risk of cardiovascular related death or hospitalization due to heart failure, after adjusting for age, gender, and left ventricular ejection fraction (all p<0.05). Conclusions: 3D-based strain analysis may be a feasible and useful diagnostic tool for discriminating the extent of myocardial dysfunction. Furthermore, it is able to provide a prognostic value beyond traditional echocardiographic parameters in terms of ejection fraction. ? 2014 Chang et al.
SDGs
Other Subjects
brain natriuretic peptide; biological marker; brain natriuretic peptide; adult; age; Article; biomechanics; body mass; controlled study; death; diagnostic test accuracy study; diastolic heart failure; female; gender; heart failure; heart function; heart left ventricle ejection fraction; heart rate; hospitalization; human; hypertension; major clinical study; male; middle aged; prognosis; protein blood level; receiver operating characteristic; retrospective study; risk factor; sensitivity and specificity; systolic heart failure; three dimensional echocardiography; ultrasound scanner; ultrasound transducer; aged; blood; case control study; Doppler echocardiography; echography; evaluation study; heart failure; heart ventricle function; three dimensional echocardiography; Adult; Aged; Biomarkers; Case-Control Studies; Echocardiography, Doppler; Echocardiography, Three-Dimensional; Female; Heart Failure; Humans; Hypertension; Male; Middle Aged; Natriuretic Peptide, Brain; Ventricular Function
Publisher
Public Library of Science
Type
journal article