https://scholars.lib.ntu.edu.tw/handle/123456789/536505
標題: | Next-generation sequencing in the genetics of human atrial fibrillation | 作者: | Hsieh C.-S. Chuang E.Y. JYH-MING JIMMY JUANG HWANG, JUEY-JEN Tseng C.-D. FU-TIEN CHIANG LING-PING LAI JIUNN-LEE LIN CHIA-TI TSAI |
公開日期: | 2013 | 卷: | 29 | 期: | 4 | 起(迄)頁: | 317-322 | 來源出版物: | Acta Cardiologica Sinica | 摘要: | The International Human Genome Sequencing Consortium published the first draft of the human genome in the journal Nature in February 2001, providing the sequence of the entire genome's three billion base pairs. The Human Genome Project involves a concerted effort to better understand the human DNA sequence through identification of all the genes. The knowledge that can be derived from the genome could result in the development of novel diagnostic assays, targeted therapies and the improved ability to predict the onset, severity and progression of diseases. This has been made possible by many parallelized, high-throughput technologies such as next-generation sequencing. In this review, we discuss the possible application of next-generation sequencing in finding the susceptibility gene(s) or diseasemechanism of an important human arrhythmia called atrial fibrillation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880593812&partnerID=40&md5=7f3479cf1cc6304421d2c41bffe287e8 https://scholars.lib.ntu.edu.tw/handle/123456789/536505 |
ISSN: | 1011-6842 | SDG/關鍵字: | DNA; RNA; article; chromatin immunoprecipitation; DNA sequence; exome; gene sequence; gene technology; general medical device; genetic association; genetic susceptibility; heart atrium fibrillation; heritability; human; metagenomics; next generation sequencing; nonhuman; RNA sequence |
顯示於: | 醫學系 |
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