Next-generation sequencing in the genetics of human atrial fibrillation
Journal
Acta Cardiologica Sinica
Journal Volume
29
Journal Issue
4
Pages
317-322
Date Issued
2013
Author(s)
Hsieh C.-S.
Chuang E.Y.
Tseng C.-D.
Abstract
The International Human Genome Sequencing Consortium published the first draft of the human genome in the journal Nature in February 2001, providing the sequence of the entire genome's three billion base pairs. The Human Genome Project involves a concerted effort to better understand the human DNA sequence through identification of all the genes. The knowledge that can be derived from the genome could result in the development of novel diagnostic assays, targeted therapies and the improved ability to predict the onset, severity and progression of diseases. This has been made possible by many parallelized, high-throughput technologies such as next-generation sequencing. In this review, we discuss the possible application of next-generation sequencing in finding the susceptibility gene(s) or diseasemechanism of an important human arrhythmia called atrial fibrillation.
SDGs
Other Subjects
DNA; RNA; article; chromatin immunoprecipitation; DNA sequence; exome; gene sequence; gene technology; general medical device; genetic association; genetic susceptibility; heart atrium fibrillation; heritability; human; metagenomics; next generation sequencing; nonhuman; RNA sequence
Type
journal article