https://scholars.lib.ntu.edu.tw/handle/123456789/536581
標題: | Angiotensinogen gene haplotype and hypertension: Interaction with ACE gene I allele | 作者: | CHIA-TI TSAI Fallin D. FU-TIEN CHIANG HWANG, JUEY-JEN LING-PING LAI Hsu K.-L. Tseng C.-D. Liau C.-S. Tseng Y.-Z. |
公開日期: | 2003 | 卷: | 41 | 期: | 1 | 起(迄)頁: | 9-15 | 來源出版物: | Hypertension | 摘要: | There are many reports demonstrating the association of renin-angiotensin system gene polymorphisms with hypertension in different populations. In the present study, we used haplotype analyses of the angiotensinogen gene with a new permutation-based hypothesis testing method to determine the association between multilocus angiotensinogen gene polymorphisms and hypertension in a relatively homogeneous Taiwanese population. We also genotyped angiotensin-converting enzyme gene insertion/deletion polymorphism and angiotensin II type 1-receptor gene A1166C polymorphism to detect epistatic gene-gene interactions. There were 408 patients with hypertension (hypertensives) and 286 controls. The angiotensinogen gene haplotype frequencies were significantly different between hypertensives and controls, and this finding was only present in subjects with angiotensin-converting enzyme gene II genotypes when the analysis was stratified by genotype of this polymorphism. In addition, the angiotensinogen gene haplotype structure of hypertensives was more heterogeneous than that of controls. Our results showed that angiotensinogen gene haplotypes were associated with hypertension and might act synergistically with I allele of the angiotensin-converting enzyme gene. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037217399&doi=10.1161%2f01.HYP.0000045080.28739.12&partnerID=40&md5=c03c655844759258d398b24df67662d8 https://scholars.lib.ntu.edu.tw/handle/123456789/536581 |
ISSN: | 0194-911X | DOI: | 10.1161/01.HYP.0000045080.28739.12 | SDG/關鍵字: | angiotensin 1 receptor; angiotensinogen; dipeptidyl carboxypeptidase; adult; article; controlled study; DNA polymorphism; epistasis; female; gene deletion; gene frequency; gene insertion; gene interaction; gene linkage disequilibrium; genotype; haplotype; human; hypertension; major clinical study; male; priority journal; renin angiotensin aldosterone system; Taiwan; Alleles; Angiotensinogen; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Hypertension; Linkage Disequilibrium; Male; Middle Aged; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Receptors, Angiotensin |
顯示於: | 醫學系 |
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