https://scholars.lib.ntu.edu.tw/handle/123456789/536584
標題: | Relation of Chlamydia pneumoniae infection in Taiwan to angiographically demonstrated coronary artery disease and to the presence of acute myocardial infarction or unstable angina pectoris | 作者: | CHIA-TI TSAI JIA-HORNG KAO Hsu K.-L. FU-TIEN CHIANG Tseng C.-D. Liau C.-S. Tseng Y.-Z. HWANG, JUEY-JEN |
公開日期: | 2001 | 卷: | 88 | 期: | 9 | 起(迄)頁: | 960-963 | 來源出版物: | American Journal of Cardiology | 摘要: | Reports of the association of Chlamydia pneumoniae (C. pneumoniae) infection with coronary artery disease (CAD) are scarce in the Oriental population. We therefore conducted a case-control study to explore this issue in Taiwan. There were 242 consecutive subjects (166 men and 76 women) who underwent cardiac catheterization at the National Taiwan University Hospital Cardiac Catheterization Laboratory. Patients with CAD (n = 156) had ?1 coronary artery lesion of >50% diameter stenosis on angiography. Controls (n = 86) had no demonstrable CAD angiographically. Antibodies to C. pneumoniae were tested by using an enzyme-linked immunosorbent assay. The prevalence of antibodies to C. pneumoniae was as follows: immunoglobulin-G (IgG), 50% (122 of 242 patients); immunoglobulin-A (IgA), 72% (176 of 242 patients); and either IgG or IgA, 79% (192 of 242 patients ). The odds ratio (OR) for CAD with either IgG or IgA was 1.4 (95% confidence interval [CI] 0.7 to 2.7, p = 0.31). After adjusting for the known CAD risk factors, the OR decreased to 0.8 (95% CI 0.3 to 2.1, p = 0.60). The OR for unstable angina or acute myocardial infarction with the presence of either IgG or IgA was 0.5 (95% CI 0.2 to 1.1, p = 0.08) and 0.4 ( 95% CI 0.1 to 1.0, p = 0.049) after adjusting for other risk factors. These results suggest a high prevalence of C. pneumoniae infection in Taiwan. However, C. pneumoniae infection is not associated with angiographically documented CAD, and, in contrast, is a negative predictor for the development of acute coronary syndromes. ? 2001 by Excerpta Medica, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035499966&doi=10.1016%2fS0002-9149%2801%2901970-1&partnerID=40&md5=a6716038914761bffb9fae54952b838e https://scholars.lib.ntu.edu.tw/handle/123456789/536584 |
ISSN: | 0002-9149 | DOI: | 10.1016/S0002-9149(01)01970-1 | SDG/關鍵字: | bacterium antibody; immunoglobulin A; immunoglobulin G; acute heart infarction; adult; aged; angiocardiography; antibody titer; article; chlamydiasis; Chlamydophila pneumoniae; controlled study; coronary artery disease; coronary artery obstruction; disease association; enzyme linked immunosorbent assay; female; heart catheterization; human; major clinical study; male; prediction; priority journal; risk assessment; risk factor; seroprevalence; Taiwan; unstable angina pectoris; Aged; Angina, Unstable; Case-Control Studies; Chlamydophila Infections; Chlamydophila pneumoniae; Coronary Angiography; Coronary Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prevalence; Seroepidemiologic Studies; Taiwan |
顯示於: | 醫學系 |
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