https://scholars.lib.ntu.edu.tw/handle/123456789/536718
標題: | Restoration of heart rate turbulence by titrated beta-blocker therapy in patients with advanced congestive heart failure: Positive correlation with enhanced vagal modulation of heart rate | 作者: | LIAN-YU LIN HWANG, JUEY-JEN LING-PING LAI Chan H.-L. Du C.-C. Tseng Y.-Z. JIUNN-LEE LIN |
公開日期: | 2004 | 卷: | 15 | 期: | 7 | 起(迄)頁: | 752-756 | 來源出版物: | Journal of Cardiovascular Electrophysiology | 摘要: | Introduction: Heart rate turbulence (HRT) is a powerful novel predictor for cardiovascular mortality. Chronic congestive heart failure is associated with abnormal HRT. Whether antiadrenergic beta-blocker therapy can restore control of HRT in patients with chronic congestive heart failure is unknown. Methods and Results: A 24-hour Holter ECG recording was obtained before and 1 and 3 months after titrated addition of atenolol therapy in 10 consecutive patients with advanced congestive heart failure. Two parameters derived from HRT, turbulence slope (TS) and turbulence onset (TO), and time- and frequency-domain heart rate variability (HRV) parameters (SDNN, RMSSD, VLF, LF, HF) from 24-hour ECG were compared before and after beta-blocker therapy, together with the same parameters in age-matched normal control. Results showed that TS (3.1 ± 2.2 vs 6.2 ± 3.0; P = 0.001) and all HRV parameters were increased after 3 months of atenolol treatment. No changes in TO were evident (0.6 ± 0.5 vs -0.2 ± 1.3; P = 0.13). The improvement of TS and the vagally mediated parameters of mean R-R interval, RMSSD, and the HF component of HRV were positively correlated. Conclusion: Abnormal HRT caused by chronic congestive heart failure can be restored by beta-blocker therapy. The evolution of TS was positively correlated with measures of vagal modulation of heart rate. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-3242667725&doi=10.1046%2fj.1540-8167.2004.03289.x&partnerID=40&md5=f92d14842ca77b777321e94b8acf219a https://scholars.lib.ntu.edu.tw/handle/123456789/536718 |
ISSN: | 1045-3873 | DOI: | 10.1046/j.1540-8167.2004.03289.x | SDG/關鍵字: | atenolol; beta adrenergic receptor blocking agent; adult; aged; article; clinical article; congestive heart failure; controlled study; correlation analysis; disease association; female; heart rate; heart rate variability; Holter monitoring; human; male; onset age; priority journal; radiofrequency; recording; Adrenergic beta-Antagonists; Aged; Analysis of Variance; Atenolol; Case-Control Studies; Chi-Square Distribution; Electrocardiography, Ambulatory; Female; Heart Failure, Congestive; Heart Rate; Humans; Linear Models; Male; Middle Aged; Prospective Studies; Treatment Outcome |
顯示於: | 醫學系 |
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