Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Use of Lactobacillus casei rhamnosus to Prevent Cholangitis in Biliary Atresia After Kasai Operation
 
  • Details

Use of Lactobacillus casei rhamnosus to Prevent Cholangitis in Biliary Atresia After Kasai Operation

Journal
Journal of pediatric gastroenterology and nutrition
Journal Volume
60
Journal Issue
5
Pages
654-658
Date Issued
2015
Author(s)
Lien T.-H.
Bu L.-N.
JIA-FENG WU  
HUEY-LING CHEN  
Chen A.-C.
Lai M.-W.
Shih H.-H.
Lee I.-H.
HONG-YUAN HSU  
YEN-HSUAN NI  
MEI-HWEI CHANG  
DOI
10.1097/MPG.0000000000000676
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027949873&doi=10.1097%2fMPG.0000000000000676&partnerID=40&md5=f1dc3a71689161b4549d055ca7603e8f
https://scholars.lib.ntu.edu.tw/handle/123456789/536950
Abstract
OBJECTIVES: Recurrent cholangitis may aggravate cholestatic liver cirrhosis in biliary atresia (BA) after the Kasai operation. This pilot study aimed to investigate whether Lactobacillus casei rhamnosus has the prophylactic efficacy for recurrent cholangitis in comparison with the conventional neomycin prophylaxis.METHODS: Twenty jaundice-free patients with BA ages 0 to 3 years who underwent a Kasai operation were enrolled and randomized into 2 groups with 10 patients each: neomycin (25 mg · kg · day for 4 days/wk) and L casei rhamnosus (8?×?10 colony-forming unit per day) groups. The treatment duration was 6 months. Bacterial stool cultures were performed before treatment and 1, 3, and 6 months after starting treatment. In addition, 10 patients with BA with similar status but without prophylaxis served as the historical control group.RESULTS: In the Lactobacillus group, 2 patients (20%, mean 0.03?±?0.07 episodes per month) developed cholangitis during the study period, with the same frequency as in the neomycin group and significantly lower than that in the control group (80%, P?=?0.005, mean 0.22?±?0.16 episodes per month). The mean change in body weight z score during the 6 months in the Lactobacillus group was 0.97?±?0.59, which was significantly better than that in the control group (-0.01?±?0.79, P?=?0.006). In bacterial stool cultures, the Lactobacillus and Escherichia coli populations significantly increased and decreased, respectively, in the Lactobacillus group.CONCLUSIONS: The use of L casei rhamnosus was as effective as neomycin in preventing cholangitis in patients with BA who underwent Kasai operation, and therefore could be considered as a potential alternative prophylactic regimen.
SDGs

[SDGs]SDG3

Other Subjects
antiinfective agent; neomycin; probiotic agent; adverse effects; Biliary Atresia; body weight; cholangitis; comparative study; controlled study; disease free survival; Escherichia coli; feces; female; human; infant; isolation and purification; Lactobacillus; Lactobacillus casei; Lactobacillus rhamnosus; male; microbiology; newborn; pilot study; portoenterostomy; randomized controlled trial; recurrent disease; Anti-Bacterial Agents; Biliary Atresia; Body Weight; Cholangitis; Disease-Free Survival; Escherichia coli; Feces; Female; Humans; Infant; Infant, Newborn; Lactobacillus; Lactobacillus casei; Lactobacillus rhamnosus; Male; Neomycin; Pilot Projects; Portoenterostomy, Hepatic; Probiotics; Recurrence
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science