https://scholars.lib.ntu.edu.tw/handle/123456789/536972
標題: | Copy-number variations in hepatoblastoma associate with unique clinical features | 作者: | JIA-FENG WU Lee C.-H. HUEY-LING CHEN YEN-HSUAN NI HONG-YUAN HSU Sheu J.-C. Tsuei D.-J. MEI-HWEI CHANG |
公開日期: | 2013 | 卷: | 7 | 期: | 1 | 起(迄)頁: | 208-214 | 來源出版物: | Hepatology International | 摘要: | Purpose: Hepatoblastoma is a rare childhood liver malignancy with limited relevant cytogenetic data. This study aimed to discover common genomic copy-number variations (CNVs) in subjects with hepatobalstoma and its relevance to the clinical course. Methods: Gene copy-number was systemically rated by high-resolution comparative genomic hybridization (CGH) DNA oligonucleotide microarray. The study group consisted of 12 children (7 males and 5 females) with hepatoblastoma and another 20 healthy individuals (10 males and 10 females) as controls. The influence of recurrent CNVs on clinical outcomes was analyzed. Results: Four highly recurrent CNVs were identified in these 12 hepatoblastoma children after comparison with controls, including a gain on 1p13.3 (n = 3, 25%) and losses on 5p15.33 (n = 4, 33.3%), 16q12.2 (n = 4, 33.3%), and 19q13.42 (n = 3, 25%). The most prevalent sites of genomic deletion were 5p15.33 and 16q12.2. Zinc finger, DHHC-type containing 11 (ZDHHC11) and DHHC-type containing 11B (ZDHHC11B) were mapped to 5p15.33, which was associated with a lower rate of survival with native liver (p = 0.03). The carboxylesterase 4-like (CES4) gene that mapped to 16q12.2 was associated with smaller tumor size at presentation. Conclusions: Deletions of 5p15.33 (33.3%) and 16q12.2 (33.3%) are the most frequent hepatoblastoma-related events in our patient group with 5p15.33 microdeletion as a potential biomarker for the fate of survival with native liver. ? 2012 Asian Pacific Association for the Study of the Liver. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875271173&doi=10.1007%2fs12072-012-9350-y&partnerID=40&md5=a367c43604456dc2de61721d7bc5ac62 https://scholars.lib.ntu.edu.tw/handle/123456789/536972 |
ISSN: | 1936-0533 | DOI: | 10.1007/s12072-012-9350-y | SDG/關鍵字: | carboxylesterase; cisplatin; DNA; doxorubicin; unclassified drug; zinc finger DHHC type containing 11 protein; zinc finger DHHC type containing 11B protein; zinc finger protein; adjuvant therapy; article; cancer mortality; cancer prognosis; cancer survival; carboxylesterase 4 like gene; child; chromosome 16q; chromosome 19q; chromosome 1p; chromosome 5p; chromosome deletion; chromosome loss; chromosome map; clinical article; clinical feature; comparative genomic hybridization; controlled study; copy number variation; disease association; DNA microarray; female; gene; gene deletion; gene dosage; hepatoblastoma; human; infant; liver resection; liver transplantation; male; nucleotide sequence; preschool child; priority journal; recurrence free survival; tumor volume |
顯示於: | 醫學系 |
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