https://scholars.lib.ntu.edu.tw/handle/123456789/536991
標題: | Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV | 作者: | HUEY-LING CHEN Lin L.-H. Hu F.-C. JIAN-TE LEE Lin W.-T. Yang Y.-J. Huang F.-C. Wu S.-F. Chen S.C.-C. Wen W.-H. Chu C.-H. YEN-HSUAN NI HONG-YUAN HSU Tsai P.-L. Chiang C.-L. MING-KWANG SHYU PING-ING LEE Chang F.-Y. MEI-HWEI CHANG |
公開日期: | 2012 | 出版社: | W.B. Saunders | 卷: | 142 | 期: | 4 | 起(迄)頁: | 773-781 | 來源出版物: | Gastroenterology | 摘要: | Background & Aims: Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There has been much debate about screening pregnant women and administering hepatitis B immunoglobulin (HBIG) to newborns. We analyzed the rate of HBV infection among children born to hepatitis B surface antigen (HBsAg)-positive mothers and whether HBIG administration reduces transmission. Methods: We analyzed data from 2356 children born to HBsAg-positive mothers, identified through prenatal maternal screens. In addition to HBV vaccines, HBIG was given to all 583 children with hepatitis B e antigen (HBeAg)-positive mothers and to 723 of 1773 children with HBeAg-negative mothers. Serology tests for HBV were performed from 2007 to 2009, when children were 0.510 years old. Results: A significantly greater percentage of children with HBeAg-positive mothers tested positive for antibodies against the hepatitis B core protein (16.76%) and HBsAg (9.26%) than children with HBeAg-negative mothers (1.58% and 0.29%, respectively; P <.0001 and <.001). Among the HBV-infected children, the rate of chronicity also was higher among children with HBeAg-positive mothers than children with HBeAg-negative mothers (54% vs 17%; P =.002). Similar rates of antibodies against the hepatitis B core protein (0.99% and 1.88%; P =.19) and HBsAg (0.14% and 0.29%; P =.65) were noted in children born to HBeAg-negative mothers who were or were not given HBIG. Infantile fulminant hepatitis developed in 1 of 1050 children who did not receive HBIG (.095%). Conclusions: Children born to HBeAg-positive mothers are at greatest risk for chronic HBV infection (9.26%), despite immunization. Administration of HBIG to infants born to HBeAg-negative mothers did not appear to reduce the rate of chronic HBV infection, but might prevent infantile fulminant hepatitis. Screening pregnant women for HBsAg and HBeAg might control mother-to-infant transmission of HBV. ? 2012 AGA Institute. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859413328&doi=10.1053%2fj.gastro.2011.12.035&partnerID=40&md5=bb34d81c03f7e2af4bcd333a76137238 https://scholars.lib.ntu.edu.tw/handle/123456789/536991 |
ISSN: | 0016-5085 | DOI: | 10.1053/j.gastro.2011.12.035 | SDG/關鍵字: | hepatitis B antibody; hepatitis B core antibody; hepatitis B surface antibody; hepatitis B surface antigen; hepatitis B vaccine; hepatitis B(e) antigen; article; child; chronicity; controlled study; drug efficacy; female; fulminant hepatic failure; hepatitis B; Hepatitis B virus; human; humoral immunity; immunization; infant; infant disease; infection rate; major clinical study; male; newborn; prenatal screening; preschool child; priority journal; school child; screening test; serology; vertical transmission; virology |
顯示於: | 醫學系 |
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