https://scholars.lib.ntu.edu.tw/handle/123456789/536991
DC Field | Value | Language |
---|---|---|
dc.contributor.author | HUEY-LING CHEN | en_US |
dc.contributor.author | Lin L.-H. | en_US |
dc.contributor.author | Hu F.-C. | en_US |
dc.contributor.author | JIAN-TE LEE | en_US |
dc.contributor.author | Lin W.-T. | en_US |
dc.contributor.author | Yang Y.-J. | en_US |
dc.contributor.author | Huang F.-C. | en_US |
dc.contributor.author | Wu S.-F. | en_US |
dc.contributor.author | Chen S.C.-C. | en_US |
dc.contributor.author | Wen W.-H. | en_US |
dc.contributor.author | Chu C.-H. | en_US |
dc.contributor.author | YEN-HSUAN NI | en_US |
dc.contributor.author | HONG-YUAN HSU | en_US |
dc.contributor.author | Tsai P.-L. | en_US |
dc.contributor.author | Chiang C.-L. | en_US |
dc.contributor.author | MING-KWANG SHYU | en_US |
dc.contributor.author | PING-ING LEE | en_US |
dc.contributor.author | Chang F.-Y. | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.creator | Chen H.-L.;Lin L.-H.;Hu F.-C.;Lee J.-T.;Lin W.-T.;Yang Y.-J.;Huang F.-C.;Wu S.-F.;Chen S.C.-C.;Wen W.-H.;Chu C.-H.;Ni Y.-H.;Hsu H.;Tsai P.-L.;Chiang C.-L.;Shyu M.-K.;Lee P.-I.;Chang F.-Y.;Mei-Hwei Chang | - |
dc.date.accessioned | 2021-01-04T07:33:47Z | - |
dc.date.available | 2021-01-04T07:33:47Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0016-5085 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859413328&doi=10.1053%2fj.gastro.2011.12.035&partnerID=40&md5=bb34d81c03f7e2af4bcd333a76137238 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/536991 | - |
dc.description.abstract | Background & Aims: Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There has been much debate about screening pregnant women and administering hepatitis B immunoglobulin (HBIG) to newborns. We analyzed the rate of HBV infection among children born to hepatitis B surface antigen (HBsAg)-positive mothers and whether HBIG administration reduces transmission. Methods: We analyzed data from 2356 children born to HBsAg-positive mothers, identified through prenatal maternal screens. In addition to HBV vaccines, HBIG was given to all 583 children with hepatitis B e antigen (HBeAg)-positive mothers and to 723 of 1773 children with HBeAg-negative mothers. Serology tests for HBV were performed from 2007 to 2009, when children were 0.510 years old. Results: A significantly greater percentage of children with HBeAg-positive mothers tested positive for antibodies against the hepatitis B core protein (16.76%) and HBsAg (9.26%) than children with HBeAg-negative mothers (1.58% and 0.29%, respectively; P <.0001 and <.001). Among the HBV-infected children, the rate of chronicity also was higher among children with HBeAg-positive mothers than children with HBeAg-negative mothers (54% vs 17%; P =.002). Similar rates of antibodies against the hepatitis B core protein (0.99% and 1.88%; P =.19) and HBsAg (0.14% and 0.29%; P =.65) were noted in children born to HBeAg-negative mothers who were or were not given HBIG. Infantile fulminant hepatitis developed in 1 of 1050 children who did not receive HBIG (.095%). Conclusions: Children born to HBeAg-positive mothers are at greatest risk for chronic HBV infection (9.26%), despite immunization. Administration of HBIG to infants born to HBeAg-negative mothers did not appear to reduce the rate of chronic HBV infection, but might prevent infantile fulminant hepatitis. Screening pregnant women for HBsAg and HBeAg might control mother-to-infant transmission of HBV. ? 2012 AGA Institute. | - |
dc.publisher | W.B. Saunders | - |
dc.relation.ispartof | Gastroenterology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hepatitis B antibody; hepatitis B core antibody; hepatitis B surface antibody; hepatitis B surface antigen; hepatitis B vaccine; hepatitis B(e) antigen; article; child; chronicity; controlled study; drug efficacy; female; fulminant hepatic failure; hepatitis B; Hepatitis B virus; human; humoral immunity; immunization; infant; infant disease; infection rate; major clinical study; male; newborn; prenatal screening; preschool child; priority journal; school child; screening test; serology; vertical transmission; virology | - |
dc.title | Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1053/j.gastro.2011.12.035 | - |
dc.identifier.scopus | 2-s2.0-84859413328 | - |
dc.relation.pages | 773-781 | - |
dc.relation.journalvolume | 142 | - |
dc.relation.journalissue | 4 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.dept | Obstetrics&Gynecology-NTUHYL | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.orcid | 0000-0002-4074-5838 | - |
crisitem.author.orcid | 0000-0002-2567-5501 | - |
crisitem.author.orcid | 0000-0002-1158-5249 | - |
crisitem.author.orcid | 0000-0002-5720-4835 | - |
crisitem.author.orcid | 0000-0001-9057-4101 | - |
crisitem.author.orcid | 0000-0002-7299-2825 | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 醫學系 |
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