https://scholars.lib.ntu.edu.tw/handle/123456789/537020
標題: | Breakthrough HBV infection in vaccinated children in Taiwan: Surveillance for HBV mutants | 作者: | MEI-HWEI CHANG | 公開日期: | 2010 | 出版社: | International Medical Press Ltd | 卷: | 15 | 期: | 3 PART B | 起(迄)頁: | 463-469 | 來源出版物: | Antiviral Therapy | 摘要: | The universal HBV vaccination programme in Taiwan has effectively led to the reduction of acute and chronic hepatitis B, and of hepatocellular carcinoma among vaccinated children. Seropositivity rates for hepatitis B surface antigen (HBsAg) decreased from 10-17% in those born before the start of the vaccination programme to the current 0.5-1.7%. Nonetheless, breakthrough infection continues to be observed. The main causes include high maternal viral load, intrauterine infection, emergence of S gene mutants and immunosuppression. Among vaccinated individuals with breakthrough HBV infection, sG145R & sT126A/S mutations (which account for 48% of the mutants detected) have become prominent. However, owing to the marked reduction in the HBsAg carrier rate, the prevalence rate of S gene mutants in the total vaccinated population has not increased. With limited evidence of spread, S gene mutants do not need to be incorporated into the HBV vaccine. Further studies are required to design better strategies to prevent breakthrough HBV infection of both wild-type and S gene mutants. ?2010 International Medical Press. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953423810&doi=10.3851%2fIMP1555&partnerID=40&md5=deba6b21ab69755d17eeba5f17de6d28 https://scholars.lib.ntu.edu.tw/handle/123456789/537020 |
ISSN: | 1359-6535 | DOI: | 10.3851/IMP1555 | SDG/關鍵字: | hepatitis B antibody; hepatitis B surface antigen; hepatitis B vaccine; hepatitis B vaccine; child; drug cost; drug efficacy; hepatitis B; Hepatitis B virus; human; immune deficiency; infection prevention; intrauterine infection; liver cell carcinoma; mass immunization; nonhuman; preschool child; priority journal; review; school child; Taiwan; virus gene; virus load; virus mutant; wild type; adolescent; blood; genetics; health survey; hepatitis B; Hepatitis B virus; heterozygote; immunology; mutation; prevalence; procedures; statistics and numerical data; transmission; vaccination; virology; Adolescent; Carrier State; Child; Child, Preschool; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B virus; Humans; Mutation; Population Surveillance; Prevalence; Taiwan; Vaccination |
顯示於: | 醫學系 |
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