https://scholars.lib.ntu.edu.tw/handle/123456789/537022
標題: | Effect of Puberty Onset on Spontaneous Hepatitis B Virus e Antigen Seroconversion in Men | 作者: | JIA-FENG WU Tsai W. HONG-YUAN HSU YEN-HSUAN NI HUEY-LING CHEN Tsuei D. MEI-HWEI CHANG |
公開日期: | 2010 | 出版社: | W.B. Saunders | 卷: | 138 | 期: | 3 | 起(迄)頁: | 942-948 | 來源出版物: | Gastroenterology | 摘要: | Background: Male predominance is a remarkable phenomenon in hepatitis B virus (HBV)-related liver disease. This study elucidated the effects of puberty on spontaneous hepatitis B virus e antigen (HBeAg) seroconversion in boys. Methods: One-hundred HBeAg-positive chronic HBV-infected males recruited at younger than 10 years of age who had been followed for >10 years were selected randomly from our long-term followed cohort into this study. Serum testosterone levels, androgen receptor exon-1 CAG repeat number and steroid 5α reductase type II (SRD5A2, valine vs leucine alleles) polymorphism were determined. Serial clinical data, HBV genotype, and spontaneous HBeAg seroconversion age were also analyzed. Results: Seventy-two subjects had spontaneous HBeAg seroconversion during the follow-up period. Subjects with serum testosterone levels ?2.5 ng/mL at 15 years old (earlier-onset puberty, n = 87) had earlier HBeAg seroconversion (median age, 13.2 vs 22.5 years; hazard ratio = 2.95; P = .005), higher peak alanine aminotransferase levels when HBeAg positive (305.7 ± 372.7 vs 154.8 ± 126.0 IU/L; P = .006), and a greater HBV viral load reduction from 10 to 20 years of age (1.6 ± 2.4 vs 0.2 ± 1.4 log10 copies/mL; P = .009) than those with serum testosterone levels <2.5 ng/mL (later-onset puberty, n = 13). Valine allele carrier at the SRD5A2 V89L polymorphism was also associated with earlier spontaneous HBeAg seroconversion (median age, 11.7 vs 18.7 years; hazard ratio = 1.88; P = .028). Conclusion: Earlier-onset puberty and increased SRD5A2 enzyme activity are associated with earlier HBeAg seroconversion, higher serum alanine aminotransferase levels, and a greater HBV viral load decrement in chronic HBV infected males. ? 2010 AGA Institute. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77249167734&doi=10.1053%2fj.gastro.2009.11.051&partnerID=40&md5=0b933d58f200e17880997ac0a9e7f056 https://scholars.lib.ntu.edu.tw/handle/123456789/537022 |
ISSN: | 0016-5085 | DOI: | 10.1053/j.gastro.2009.11.051 | SDG/關鍵字: | alanine aminotransferase; androgen receptor; hepatitis E antigen; steroid 5alpha reductase 2; adolescent; adulthood; allele; article; child; clinical trial; controlled clinical trial; controlled study; DNA polymorphism; exon; follow up; genotype; hepatitis B; human; major clinical study; male; preschool child; priority journal; puberty; randomized controlled trial; school child; seroconversion; testosterone blood level; virus load |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。