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  4. Humoral immunogenicity to measles, rubella, and varicella-zoster vaccines in biliary atresia children
 
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Humoral immunogenicity to measles, rubella, and varicella-zoster vaccines in biliary atresia children

Journal
Vaccine
Journal Volume
27
Journal Issue
21
Pages
2812-2815
Date Issued
2009
Author(s)
JIA-FENG WU  
YEN-HSUAN NI  
HUEY-LING CHEN  
HONG-YUAN HSU  
HONG-SHIEE LAI  
MEI-HWEI CHANG  
DOI
10.1016/j.vaccine.2009.02.094
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-64449083709&doi=10.1016%2fj.vaccine.2009.02.094&partnerID=40&md5=39d121c7d96ed9082c25c1212c12678f
https://scholars.lib.ntu.edu.tw/handle/123456789/537031
Abstract
To investigate the humoral immune response to measles, rubella, and varicella-zoster virus (VZV) vaccines in biliary atresia (BA) children before liver transplantation, we conducted the cross-sectional designed study. Fifty BA children (age, 3.6 ± 0.2 years; 24 girls) who had not yet received liver transplantation, and another 150 healthy controls (age, 4.0 ± 0.1 years; 78 girls) were recruited into this study to evaluate their primary humoral immune response to measles, rubella, and VZV vaccines. All of these BA children (n = 50) and controls (n = 150) received one dose of measles, one dose of measles-mumps-rubella (MMR), and one dose of VZV vaccine before our assessment. Serum samples were collected at least 1 month after the vaccination and serum immunoglobulin G (IgG) antibody to measles, rubella, and VZV were then determined by qualitative enzyme-linked immune-sorbent assay. The prevalence of seropositive rate of measles IgG antibody (84% vs. 96.7%; P = 0.002), rubella (82.0% vs. 98.7%; P < 0.001), and VZV (74% vs. 95.3%; P < 0.001) were significantly different between BA children and the controls after regular measles, MMR, and VZV vaccination before 2 years of age. In those BA children with seronegative VZV antibody after vaccination, two had VZV infection after the liver transplantation. This study indicated that humoral immunity to rubella, measles and VZV vaccines are significantly lower in BA children than the normal population by standard vaccine schedule. ? 2009 Elsevier Ltd. All rights reserved.
SDGs

[SDGs]SDG3

Other Subjects
alanine aminotransferase; bilirubin; chickenpox vaccine; immunoglobulin G antibody; measles mumps rubella vaccine; measles vaccine; varicella zoster vaccine; alanine aminotransferase blood level; albumin blood level; article; bile duct atresia; blood sampling; body height; body mass; body weight; chickenpox; child; clinical article; controlled study; enzyme linked immunosorbent assay; female; human; humoral immunity; liver transplantation; male; measles; nutritional status; preschool child; prevalence; priority journal; qualitative analysis; rubella; serodiagnosis; single drug dose; statistical significance; vaccination; Varicella zoster virus; Antibody Formation; Antigens, Viral; Biliary Atresia; Child, Preschool; Cross-Sectional Studies; Female; Herpes Zoster Vaccine; Humans; Immunogenetics; Male; Measles Vaccine; Rubella Vaccine; Vaccination
Type
journal article

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