https://scholars.lib.ntu.edu.tw/handle/123456789/537032
標題: | Emerging Importance of Autoimmune Hepatitis in Children in Taiwan, an Endemic Area for Viral Hepatitis | 作者: | Yeh S.-H. YEN-HSUAN NI YUNG-MING JENG HUEY-LING CHEN JIA-FENG WU MEI-HWEI CHANG |
公開日期: | 2009 | 卷: | 50 | 期: | 2 | 起(迄)頁: | 65-69 | 來源出版物: | Pediatrics and Neonatology | 摘要: | Background: Untreated autoimmune hepatitis (AIH) can develop into liver cirrhosis, with potentially fatal outcomes. Viral hepatitis in children was endemic in Taiwan before universal hepatitis B vaccination, but AIH has rarely been reported in Taiwanese children. We performed this retrospective study to characterize the clinical features of AIH in Taiwanese children. Methods: We enrolled children with AIH, based on the revised scoring system of the International Autoimmune Hepatitis Group (IAIHG) from 383 children hospitalized with hepatitis from January 2000 to April 2008. Other etiologies of hepatitis were excluded. Results: There were three definite and six probable AIH cases. The incidence of AIH among children hospitalized with hepatitis was 2.3%. Eight children had other autoimmune diseases, including systemic lupus erythematosus (SLE) (6), discoid lupus erythematosus (DLE) (1), and autoimmune polyendocrinopathy syndrome type 1 (1). Another had biliary atresia, and AIH developed after cadaveric liver transplantation. Antinuclear antibodies ranged from 1:160-1:2560. Peak alanine aminotransferase (ALT) values were 546 ± 188 U/L (mean ± SD). Jaundice occurred in four patients. Liver histology in the three definite AIH patients showed chronic hepatitis with predominantly lymphoplasmacytic infiltrates in portal areas, with prominent interface activity. Treatment included prednisolone, azathioprine, and/or cyclosporine. All patients survived. ALT fell to < 60 U/L after treatment. Hepatitis relapse occurred in one patient. Conclusion: AIH in Taiwanese children is commoner than previously thought. It is associated with other autoimmune diseases and may occur before, simultaneously with, or after other autoimmune diseases. Children with liver transplants are also at risk of AIH. ? 2009 Taiwan Pediatric Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-65549150347&doi=10.1016%2fS1875-9572%2809%2960035-8&partnerID=40&md5=24c222467f0033475d57fc540c61f9e1 https://scholars.lib.ntu.edu.tw/handle/123456789/537032 |
ISSN: | 1875-9572 | DOI: | 10.1016/S1875-9572(09)60035-8 | SDG/關鍵字: | alanine aminotransferase; antinuclear antibody; azathioprine; cyclosporin; prednisolone; article; autoimmune hepatitis; autoimmune polyendocrinopathy; bile duct atresia; child; clinical feature; discoid lupus erythematosus; female; histopathology; hospitalization; human; incidence; jaundice; liver transplantation; lymphocytic infiltration; major clinical study; male; relapse; retrospective study; scoring system; survival; systemic lupus erythematosus; Taiwan; virus hepatitis; Adolescent; Child; Female; Hepatitis, Autoimmune; Hepatitis, Viral, Human; Humans; Male; Retrospective Studies; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。