https://scholars.lib.ntu.edu.tw/handle/123456789/537084
標題: | Long-term follow-up of hepatitis B surface antibody levels in subjects receiving universal hepatitis B vaccination in infancy in an area of hyperendemicity: Correlation between radioimmunoassay and enzyme immunoassay | 作者: | Wang C.-W. LI-CHIEH WANG MEI-HWEI CHANG YEN-HSUAN NI HUEY-LING CHEN HONG-YUAN HSU Chen D.-S. |
公開日期: | 2005 | 卷: | 12 | 期: | 12 | 起(迄)頁: | 1442-1447 | 來源出版物: | Clinical and Diagnostic Laboratory Immunology | 摘要: | The aims of the present study were to determine (i) the long-term immunogenicity and the decay rate of hepatitis B virus (HBV) surface antibody (anti-HBs) from universal hepatitis B vaccination at infancy for a healthy population in an area of hyperendemicity and (ii) whether the anti-HBs levels measured by enzyme immunoassay (EIA) were closely correlated with those assayed by radioimmunoassay (RIA) methods during long-term monitoring. A total of 1,337 apparently healthy children (696 boys and 641 girls) who were vaccinated against HBV at infancy and monitored for anti-HBs annually from 7 to 16 years of age entered the study. Serum samples were analyzed for anti-HBs by RIA at 7 to 15 years of age and were also analyzed by EIA at 13 to 16 years of age. Antibody titers were quantified in mIU/ml by EIA as well as by the ratio of the count in the sample to the count for a negative control (S/N) by RIA. In nonboosted children, the average decay of anti-HBs from 7 to 16 years of ages indicated that approximately 20% of the geometric mean titer decays per year. There was a good correlation between serum anti-HBs levels measured by the RIA and the EIA methods (r = 0.91; P < 0.0001). An equation for RIA to EIA level conversion was established: log EIA titer = -0.12 + (1.31 · log RIA S/N). The anti-HBs titers measured by EIA correlate well with the S/N assayed by RIA. The annual decay rate of the log anti-HBs level may help in planning booster immunizations for hyporesponders or individuals at risk in adolescence. Copyright ? 2005, American Society for Microbiology. All Rights Reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-29144502416&doi=10.1128%2fCDLI.12.12.1442-1447.2005&partnerID=40&md5=9096e496d544b826ab2a70e493f081ac https://scholars.lib.ntu.edu.tw/handle/123456789/537084 |
ISSN: | 1071-412X | DOI: | 10.1128/CDLI.12.12.1442-1447.2005 | SDG/關鍵字: | engerix; hepatitis B surface antibody; hepatitis B vaccine; ricombivax; adolescent; antibody titer; article; controlled study; correlation analysis; endemic disease; enzyme immunoassay; follow up; hepatitis B; Hepatitis B virus; human; immunization; immunogenicity; long term care; normal human; priority journal; quantitative analysis; radioimmunoassay; school child; vaccination; Adolescent; Child; Follow-Up Studies; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Immunization, Secondary; Immunoenzyme Techniques; Radioimmunoassay |
顯示於: | 醫學系 |
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