https://scholars.lib.ntu.edu.tw/handle/123456789/537125
標題: | Different hepatitis B virus core gene mutations in children with chronic infection and hepatocellular carcinoma | 作者: | YEN-HSUAN NI MEI-HWEI CHANG HONG-YUAN HSU Tsuei D.-J. |
公開日期: | 2003 | 卷: | 52 | 期: | 1 | 起(迄)頁: | 122-125 | 來源出版物: | Gut | 摘要: | Background: The significance of mutations of hepatitis B virus (HBV) precore/core antigen in causing persistent infection and subsequent liver diseases is debatable. Aim: To investigate HBV core gene sequence changes in children with chronic HBV infection and their implications in hepatocellular carcinoma (HCC). Methods: Thirty one chronic HBV infected children with documented hepatitis B e antigen seroconversion selected from 415 long term carrier children and 12 HBV related HCC children were studied. Four serial serum samples before and ofter hepatitis B e antigen seroconversion from each of the 31 children, and one serum sample taken from the 12 HCC children were subjected to HBV core gene sequence anolysis. Results: Mutations accumulated as chronic infection persisted and most frequently occurred at core gene codon 21 (29%), codon 147 (29%), codon 65 (16%), and precore stop codon 28 (74%) in the 31 chronic HBV infected children. Core gene mutation sites in HCC children were identified at core codons 74, 87, and 159. HCC children had more mutations in the core gene than those with chronic HBV infection (p=0.013). Conclusion: Accumulation of mutations of HBV core region in HCC children differ from those in chronic HBV infected children. This may be a clue to the pathogenesis of paediatric HCC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037214364&doi=10.1136%2fgut.52.1.122&partnerID=40&md5=3c38f0bfbcb08c1feb3812a3842ca726 https://scholars.lib.ntu.edu.tw/handle/123456789/537125 |
ISSN: | 0017-5749 | DOI: | 10.1136/gut.52.1.122 | SDG/關鍵字: | hepatitis B(e) antigen; adolescent; article; blood sampling; child; childhood cancer; chronic hepatitis; codon; controlled study; disease association; female; gene mutation; gene sequence; Hepatitis B virus; human; liver carcinogenesis; liver cell carcinoma; major clinical study; male; priority journal; sequence analysis; serodiagnosis; virus gene; Adolescent; Alanine Transaminase; Carcinoma, Hepatocellular; Case-Control Studies; Chi-Square Distribution; Child; Child, Preschool; Codon; DNA Mutational Analysis; Female; Follow-Up Studies; Hepatitis B Core Antigens; Hepatitis B, Chronic; Humans; Liver Neoplasms; Logistic Models; Male; Mutation |
顯示於: | 醫學系 |
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