https://scholars.lib.ntu.edu.tw/handle/123456789/537126
標題: | Long-term immunogenicity and efficacy of universal hepatitis B virus vaccination in Taiwan | 作者: | Lin Y.-C. MEI-HWEI CHANG YEN-HSUAN NI HONG-YUAN HSU Chen D.-S. |
公開日期: | 2003 | 卷: | 187 | 期: | 1 | 起(迄)頁: | 134-138 | 來源出版物: | Journal of Infectious Diseases | 摘要: | The long-term immunogenicity of universal hepatitis B virus (HBV) vaccine is seldom studied in large-scale prospective community-based populations, especially in adolescents. This study enrolled 1200 children aged 7 years with complete HBV immunization in infancy and determined HBV surface antigen (HBsAg), its antibody (anti-HBs), and HBV core antibody (anti-HBc) annually until the children were aged 14 years. Eleven children had new HBV infections with anti-HBc positivity as the only marker. None became positive for HBsAg or had detectable HBV DNA by polymerase chain reaction. The percentage of protective anti-HBs in 951 children without booster vaccination gradually decreased from 71.1% at age 7 years to 37.4% at age 12 years. Only 1 of the 200 children in the booster group and 2 of the 258 children in the nonbooster group developed new anti-HBc positivity. The results suggest that routine booster vaccination may not be required to provide protection against chronic HBV infection before age 15 years. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037219807&doi=10.1086%2f345871&partnerID=40&md5=4a08573b349916ea6a664e436b0afac0 https://scholars.lib.ntu.edu.tw/handle/123456789/537126 |
ISSN: | 0022-1899 | DOI: | 10.1086/345871 | SDG/關鍵字: | hepatitis B antibody; hepatitis B core antibody; hepatitis B surface antigen; hepatitis B vaccine; adolescent; adult; antibody titer; article; female; hepatitis B; human; immunization; immunogenicity; major clinical study; male; patient selection; polymerase chain reaction; priority journal; school child; seroconversion; serodiagnosis; Taiwan; vaccination; virus replication; Adolescent; Child; Female; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Immunization; Male; Taiwan; Vaccination |
顯示於: | 醫學系 |
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