https://scholars.lib.ntu.edu.tw/handle/123456789/537197
標題: | A simplified schedule to integrate the hepatitis B vaccine into an expanded program of immunization in endemic countries | 作者: | Lee C.-Y. PING-ING LEE LI-MIN HUANG JONG-MIN CHEN MEI-HWEI CHANG |
公開日期: | 1997 | 出版社: | Mosby Inc. | 卷: | 130 | 期: | 6 | 起(迄)頁: | 981-986 | 來源出版物: | Journal of Pediatrics | 摘要: | Objective: To investigate the safety, immunogenicity, and efficacy of a simplified hepatitis B vaccination schedule. Methods: The second dose of hepatitis B vaccine and the first dose of diphtheria-tetanus-pertussis (DTP) vaccine were given simultaneously at age 6 weeks. The second dose of DTP vaccine was given at age 3.5 months. The third dOSe of DTP vaccine and the third dose of hepatitis B vaccine were given at age 5.5 months. One hundred three infants (group A) born to mothers without hepatitis B surface antigen (HBsAg) received DTP with whole-cell pertussis vaccine. Fifty-five infants (group B) born to mothers with HBsAg and hepatitis B e antigen received DTP with acellular pertussis vaccine. Results: By age 9 months, none of group A and 4 (7%) group B infants were seropositive for HBsAg. The protective efficacy against the hepatitis B carrier state in these infants at high risk was 92%. Antibody to hepatitis B surface antigen was 10 mlU/ml or greater in 99 (96%) of group A infants and in 50 (91%) of group B infants. Both the acellular and whole-cell DTP vaccines were immunogenic, and the incidences of adverse reactions were within an expected and acceptable range. Conclusions: The simplified vaccination schedule to integrate the hepatitis B vaccine into the Expanded Programme of Immunization was safe, immunogenic, and effective. This schedule may improve vaccine compliance and be applied to DTP and hepatitis B combination vaccines now under investigation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030658869&doi=10.1016%2fS0022-3476%2897%2970287-7&partnerID=40&md5=a34c376a2add8d61f1b20bf717dda2b4 https://scholars.lib.ntu.edu.tw/handle/123456789/537197 |
ISSN: | 0022-3476 | DOI: | 10.1016/S0022-3476(97)70287-7 | SDG/關鍵字: | diphtheria antibody; diphtheria pertussis tetanus vaccine; hepatitis B surface antibody; hepatitis B surface antigen; hepatitis B vaccine; hepatitis B(e) antigen; oral poliomyelitis vaccine; tetanus antibody; anorexia; antibody titer; article; clinical trial; controlled clinical trial; controlled study; drug efficacy; drug formulation; drug safety; endemic disease; erythema; fever; human; immunization; immunogenicity; infant; irritability; major clinical study; oral drug administration; pain; priority journal; side effect; skin manifestation; somnolence; vomiting |
顯示於: | 醫學系 |
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