Clonal origin of recurrent hepatocellular carcinomas
Journal
Gastroenterology
Journal Volume
96
Journal Issue
2 PART 1
Pages
527-529
Date Issued
1989
Author(s)
Lai M.-Y.
Lee S.-C.
Hsu H.-C.
Sung J.-L.
Abstract
Recurrence of hepatocellular carcinoma after treatment is frequent. To study the clonal origin of the recurrent tumors, we examined five pairs of hepatocellular carcinomas resected from individual hepatitis B surface antigen carriers. Using integrated hepatitis B virus DNA as a marker, tumor clonality was determined by Southern blot analysis. In 2 cases the second tumor contained the same integrated viral DNA as the first one. In the other 3 cases, the clonality of the second cancer differed. We conclude that recurrent hepatocellular carcinomas originate from the first tumor in some cases but represent de novo neoplasms in others.
SDGs
Type
journal article