Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Clinicopathologic features and responses to radiotherapy of myeloid sarcoma
 
  • Details

Clinicopathologic features and responses to radiotherapy of myeloid sarcoma

Journal
Radiation Oncology
Journal Volume
8
Journal Issue
1
Date Issued
2013
Author(s)
WAN-YU CHEN  
CHUN-WEI WANG  
Chang C.-H.
Liu H.-H.
KENG-HSUEH LAN  
JIH-LUH TANG  
HWEI-FANG TIEN  
SUNG-HSIN KUO  
ANN-LII CHENG  
DOI
10.1186/1748-717X-8-245
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886891610&doi=10.1186%2f1748-717X-8-245&partnerID=40&md5=a9b621f18ef0eb801c569eba12305f83
https://scholars.lib.ntu.edu.tw/handle/123456789/537447
Abstract
Background: To evaluate clinicopathological features, radiotherapeutic parameters, and their associations with responses to radiotherapy (RT) in patients with myeloid sarcoma (MS).Methods: We reviewed 20 patients receiving RT for MS lesions (in 43 RT courses) and analyzed the patients' clinicopathologic features and radiotherapeutic parameters, and their associations with complete responses (CR) to RT using Fisher's exact test and univariate logistic regression analysis. Generalized Estimating Equation was used to analyze all 43 irradiated lesions and account for the correlations in RT responses among lesions from the same patient.Results: We found that the underlying hematological diseases of the evaluated patients were acute myeloid leukemia (AML) in 14 patients (70%), chronic myeloid leukemia in 4 patients (20%), myelodysplastic syndrome with AML transformation in one patient (5%), and de novo MS in one patient (5%). Most patients (55%) received RT for MS at the time of relapse following bone marrow transplantation (BMT). The most common cytogenetic abnormality was t(8;21)(q22;q22). The median RT dose of 20 Gy (range 6-35 Gy), administered in 1.5-3.5 Gy fractions, provided a 63% CR rate. RT dose, sex, cytogenetics, and bone marrow status at the time of RT had no significant effect on CR. Younger age (<50 y, P = 0.06), BMT prior to RT (P = 0.05), and underlying AML (P = 0.05) were marginally associated with higher CR to RT.Conclusions: Our results indicate that a modest RT dose (20-30 Gy) achieves good local control of MS. Age, previous BMT, and underlying hematologic disease can affect RT response. ? 2013 Chen et al.; licensee BioMed Central Ltd.
SDGs

[SDGs]SDG3

Other Subjects
antineoplastic agent; acute granulocytic leukemia; adolescent; adult; age; aged; article; bone marrow transplantation; cancer chemotherapy; cancer control; cancer palliative therapy; cancer patient; cancer radiotherapy; cancer surgery; cancer survival; chemosurgery; child; chronic myeloid leukemia; clinical article; clinical feature; controlled study; correlational study; cytogenetics; female; granulocytic sarcoma; histopathology; human; leukemia relapse; male; multimodality cancer therapy; myelodysplastic syndrome; preschool child; radiation dose fractionation; retrospective study; school child; treatment response; Kaplan Meier method; middle aged; mortality; pathology; Sarcoma, Myeloid; treatment outcome; very elderly; young adult; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Retrospective Studies; Sarcoma, Myeloid; Treatment Outcome; Young Adult
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science