Prognostic factors of treatment outcomes in patients with granulocytic sarcoma
Journal
Acta Haematologica
Journal Volume
122
Journal Issue
4
Pages
238-246
Date Issued
2009
Author(s)
Abstract
Purpose: To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS). Methods: We retrospectively investigated the prognostic factors determining survival in 24 patients with GS using Kaplan-Meier survival analysis followed by log rank tests. We evaluated gender, age, location, GS antedating leukemia, underlying disorders, treatment type and stem cell transplantation. Results: The 5-year survival rate for the patients with GS was 21%. The patients undergoing chemotherapy had a significantly longer survival time compared to those who did not (p = 0.0009). We found no difference in the 5-year survival rate among the patients undergoing chemotherapy combined with radiation or surgery. Patients with chronic myelogenous leukemia and myelodysplastic disorders had worse survival rates (p = 0.0028). Conclusion: Early diagnosis with biopsy and early chemotherapy can improve survival outcome. Local radiation or surgery can improve symptoms but does not influence survival outcomes. ? 2009 S. Karger AG, Basel.
SDGs
Other Subjects
cyclophosphamide; cytarabine; idarubicin; adolescent; adult; age distribution; aged; allogeneic hematopoietic stem cell transplantation; article; cancer chemotherapy; cancer diagnosis; cancer localization; cancer radiotherapy; cancer surgery; cancer survival; cause of death; child; chronic myeloid leukemia; clinical article; controlled study; cytogenetics; diagnostic imaging; female; follow up; granulocytic sarcoma; histopathology; human; male; medical record review; myelodysplastic syndrome; onset age; preschool child; priority journal; prognosis; school child; sex difference; stem cell transplantation; survival rate; treatment outcome; Adolescent; Adult; Aged; Antineoplastic Agents; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Kaplan-Meier Estimate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Retrospective Studies; Sarcoma, Myeloid; Translocation, Genetic; Treatment Outcome; Young Adult
Type
journal article