https://scholars.lib.ntu.edu.tw/handle/123456789/537482| Title: | Prognostic factors of treatment outcomes in patients with granulocytic sarcoma | Authors: | Lan T.-Y. Lin D.-T. HWEI-FANG TIEN RONG-SEN YANG Chen C.-Y. Wu K. |
Issue Date: | 2009 | Journal Volume: | 122 | Journal Issue: | 4 | Start page/Pages: | 238-246 | Source: | Acta Haematologica | Abstract: | Purpose: To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS). Methods: We retrospectively investigated the prognostic factors determining survival in 24 patients with GS using Kaplan-Meier survival analysis followed by log rank tests. We evaluated gender, age, location, GS antedating leukemia, underlying disorders, treatment type and stem cell transplantation. Results: The 5-year survival rate for the patients with GS was 21%. The patients undergoing chemotherapy had a significantly longer survival time compared to those who did not (p = 0.0009). We found no difference in the 5-year survival rate among the patients undergoing chemotherapy combined with radiation or surgery. Patients with chronic myelogenous leukemia and myelodysplastic disorders had worse survival rates (p = 0.0028). Conclusion: Early diagnosis with biopsy and early chemotherapy can improve survival outcome. Local radiation or surgery can improve symptoms but does not influence survival outcomes. ? 2009 S. Karger AG, Basel. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70350557176&doi=10.1159%2f000253592&partnerID=40&md5=f12981d42bbc01621c5f5b25b9ef4b81 https://scholars.lib.ntu.edu.tw/handle/123456789/537482 |
ISSN: | 0001-5792 | DOI: | 10.1159/000253592 | SDG/Keyword: | cyclophosphamide; cytarabine; idarubicin; adolescent; adult; age distribution; aged; allogeneic hematopoietic stem cell transplantation; article; cancer chemotherapy; cancer diagnosis; cancer localization; cancer radiotherapy; cancer surgery; cancer survival; cause of death; child; chronic myeloid leukemia; clinical article; controlled study; cytogenetics; diagnostic imaging; female; follow up; granulocytic sarcoma; histopathology; human; male; medical record review; myelodysplastic syndrome; onset age; preschool child; priority journal; prognosis; school child; sex difference; stem cell transplantation; survival rate; treatment outcome; Adolescent; Adult; Aged; Antineoplastic Agents; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Kaplan-Meier Estimate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Retrospective Studies; Sarcoma, Myeloid; Translocation, Genetic; Treatment Outcome; Young Adult [SDGs]SDG3 |
| Appears in Collections: | 醫學系 |
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