Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/537545
Title: Minimally differentiated acute myeloid leukemia in Taiwan: Predominantly occurs in children less than 3 years and adults between 51 and 70 years
Authors: SHANG-YI HUANG 
JIH-LUH TANG 
SHIANN-TANG JOU 
Tsay W.
Hu C.-H.
Lin D.-T.
Lin K.-S.
Lin K.-S.
Wang C.-H.
YAO-CHANG CHEN 
MING-CHING SHEN 
HWEI-FANG TIEN 
Issue Date: 1999
Publisher: Nature Publishing Group
Journal Volume: 13
Journal Issue: 10
Start page/Pages: 1506-1512
Source: Leukemia
Abstract: 
Acute myeloid leukemia (AML) with minimal differentiation was usually referred to as acute undifferentiated leukemia in the past. With the help of immunophenotyping, this subtype of leukemia was shown to express myeloid antigens on the blasts and was designated AML-MO by FAB Cooperative Study Group in 1991. Among the 423 consecutive newly diagnosed de novo AML at our institution, 12 (2.8%) were of MO subtype. The proportion of MO in AML was higher in children than in adults (8.2% vs 1.7%). Four other MO patients referred from outside hospitals for immunophenotyping were also included in this study. There were two peaks in age distribution of these 16 patients: less than 3 years and between 51 and 70 years, respectively. Organomegaly was more common in patients with AML-MO than in those with other subtypes (56.3% vs 29.2%, P = 0.025). The former patients had higher incidences of CD7 and CD34 expression on the leukemic cells than the latter ones (50% vs 16.9%, P = 0.003 and 69.2% vs 37.9%, P = 0.019, respectively). The patients with AML-MO showed more frequent clonal chromosomal abnormalities in the leukemic cells than other AML patients (83.3% vs 53.9%, P = 0.039); the same is also true for complex cytogenetic aberrations (50% vs 11.4%, P = 0.004). Adults with AML-MO showed a lower complete remission (CR) rate and significantly poorer survival than those with non MO-AML. However there was no significant difference in outcome between the two groups of pediatric patients. In conclusion, AML-MO is a unique subtype of leukemia that has distinct age distribution and shows different clinical and biological characteristics from other AML. Adult patients have poor prognosis. Whether pediatric patients had better outcome than adults needs to be clarified in further studies.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032826317&doi=10.1038%2fsj.leu.2401521&partnerID=40&md5=de96cfba2d8324b5bceada193182104e
https://scholars.lib.ntu.edu.tw/handle/123456789/537545
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2401521
SDG/Keyword: anthracycline; CD34 antigen; CD7 antigen; cyclophosphamide; cytarabine; epirubicin; etoposide; mercaptopurine; methotrexate; tioguanine; acute granulocytic leukemia; adolescent; adult; aged; antigen expression; article; blast cell; cancer classification; cancer survival; child; cytogenetics; differentiation; female; human; human cell; immunophenotyping; infant; intravenous drug administration; leukemia remission; major clinical study; male; oral drug administration; priority journal; prognosis; Taiwan
[SDGs]SDG3
Appears in Collections:醫學系

Show full item record

SCOPUSTM   
Citations

13
checked on Mar 6, 2023

WEB OF SCIENCETM
Citations

13
checked on Mar 12, 2023

Page view(s)

24
checked on Mar 23, 2023

Google ScholarTM

Check

Altmetric

Altmetric

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback