Clonal chromosomal abnormalities as direct evidence for clonality in nasal T/natural killer cell lymphomas
Journal
British Journal of Haematology
Journal Volume
97
Journal Issue
3
Pages
621-625
Date Issued
1997
Author(s)
Abstract
Nasal T/natural killer (NK) cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe. The clonal nature of the infiltrating lymphoid cells is difficult to demonstrate because of the lack of immunologic markers for clonality and the absence of clonal T-cell receptor gene rearrangement in most cases. In this study, clonal chromosomal abnormalities were detected in the tumour cells from four patients with nasal T/NK cell lymphoma. This finding provided direct evidence for clonality of the disease. Moreover, nonrandom cytogenetic abnormalities, including isochromosome for the short arm (p) of chromosome 6, isochromosome for the long arm (q) of chromosome 1, partial deletion of 6q, and aberrations at 11 q, were disclosed. Isochromosome 6p was the sole structural abnormality in one patient, which may be a pathognomonic change in nasal lymphoma.
SDGs
Other Subjects
article; cell population; chromosome aberration; clonal anergy; Epstein Barr virus; gene deletion; gene rearrangement; human; human cell; inflammatory cell; isochromosome; killer cell; lymphocytic infiltration; lymphoid cell; lymphoma; priority journal
Publisher
Blackwell Publishing Ltd
Type
journal article