https://scholars.lib.ntu.edu.tw/handle/123456789/537557
標題: | Clinical and biological characteristics of acute promyelocytic leukemia in Taiwan: A high relapse rate in patients with high initial and peak white blood cell counts during all-trans-retinoic acid treatment | 作者: | WEN-CHIEN CHOU JIH-LUH TANG MING YAO Liang Y.-J. Lee F.-Y. Lin M.-T. Wang C.-H. MING-CHING SHEN YAO-CHANG CHEN HWEI-FANG TIEN |
公開日期: | 1997 | 出版社: | Nature Publishing Group | 卷: | 11 | 期: | 7 | 起(迄)頁: | 921-928 | 來源出版物: | Leukemia | 摘要: | Acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) and chemotherapy have been shown to have better outcome than those treated with conventional chemotherapy alone. However, the biological characteristics of leukemic cells and their clinical implications in patients treated with ATRA have not been well established. In this study, the biological and clinical features of 30 APL patients were reported. The risk factors for relapse and for occurrence of retinoic acid (RA) syndrome, which might cause morbidity or mortality of patients after ATRA treatment, were also analyzed. All patients showed 15;17 translocation by cytogenetic and/or gene analysis. Patients in this study had higher white blood cell (WBC) counts and a higher incidence of additional abnormalities than those from other areas. The ratio of long (L) form to short (S) form PML-RARα fusion transcript was 1.8:1, a value lower than that of Latino patients but higher than that of Italians. Leukemic cells from four patients showed coexpression of T cell-associated antigen CD2 which was highly correlated with S form fusion transcript. Nine (36%) of the 25 patients treated with ATRA developed RA syndrome; all but one were successfully controlled by corticosteroid. Complete remission (CR) rate was 84%. Patients with high WBC counts tended to develop RA syndrome and had increased risk of relapse. Isochromosome for the long arm of the derivative chromosome 17, ider(17q), as an additional chromosomal abnormality was also associated with poor outcome in this study. In conclusion, APL in this study showed some different biological characteristics compared with those reported in other areas. High WBC count was a risk factor for relapse and development of RA syndrome after ATRA treatment. The prognostic implication of the presence of ider(l7q) needs further clarification. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-16944362111&doi=10.1038%2fsj.leu.2400690&partnerID=40&md5=57731d7373fb89a9d3426be3fb4c0160 https://scholars.lib.ntu.edu.tw/handle/123456789/537557 |
ISSN: | 0887-6924 | DOI: | 10.1038/sj.leu.2400690 | SDG/關鍵字: | CD2 antigen; corticosteroid; dexamethasone; hydroxyurea; retinoic acid; T lymphocyte antigen; acute myeloblastic leukemia; adolescent; adult; aged; article; chromosome translocation 15; chromosome translocation 17; clinical article; ethnic group; female; human; human cell; intravenous drug administration; isochromosome; leukocyte count; male; oral drug administration; priority journal; prognosis; recurrence risk; retinoic acid syndrome; Taiwan |
顯示於: | 醫學系 |
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