https://scholars.lib.ntu.edu.tw/handle/123456789/537786
標題: | Successful bone marrow transplantation in a Chinese boy with Wiskott-Aldrich syndrome | 作者: | Huang M.-T. Chou C.-C. SHIANN-TANG JOU KAI-HSIN LIN Hsieh K.-H. |
公開日期: | 1996 | 卷: | 14 | 期: | 1 | 起(迄)頁: | 57-63 | 來源出版物: | Asian Pacific Journal of Allergy and Immunology | 摘要: | We describe the successful use of HLA-compatible sibling bone marrow transplantation (BMT) in a 17-month-old Chinese boy in whom Wiskott-Aldrich syndrome (WAS) was diagnosed on the basis of eczema, thrombocytopenia, recurrent otitis media and abnormal immunological tests. The conditioning chemotherapy included 2 days' oral busulfan, 40 mg/m2/6 hours, and 2 days' intravenous cyclophosphamide, 60 mg/kg/day (BU2CY2). Complete hematological chimerism was achieved 3 weeks after transplantation. Eight months after his BMT the eczema has resolved, platelet count is normal, and he no longer has frequent infections. BU2CY2 as a preconditioning regimen gave complete lymphohematopoietic engraftment in this WAS patient with no evidence of graft- versus- host disease. The excellent clinical response of this patient and the inevitable fatal outcome of WAS support the opinion that where a histocompatible donor is available, BMT at the earliest opportunity is the best option. We believe this is the first case of successful BMT in a Chinese patient with WAS. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030418645&partnerID=40&md5=e64b28b34f4a47e3e246ceb2755581b2 https://scholars.lib.ntu.edu.tw/handle/123456789/537786 |
ISSN: | 0125-877X | SDG/關鍵字: | busulfan; cyclophosphamide; immunosuppressive agent; article; bone marrow transplantation; case report; child; chinese; eczema; human; intravenous drug administration; male; oral drug administration; otitis media; preschool child; thrombocytopenia; wiskott aldrich syndrome; Asian Continental Ancestry Group; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Humans; Infant; Male; Wiskott-Aldrich Syndrome |
顯示於: | 醫學系 |
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