Complete response of myeloid sarcoma with cardiac involvement to radiotherapy
Journal
Journal of Thoracic Disease
Journal Volume
8
Journal Issue
6
Pages
1323-1328
Date Issued
2016
Author(s)
Abstract
We present a rare case of intracardiac myeloid sarcoma (MS) of acute myeloid leukemia (AML) and who responds completely well to low-dose radiotherapy. This 19-year-old young man initially presented with AML and received standard chemotherapy followed by allogeneic hematopoietic stem cell transplantation (HSCT). However, he developed intracardiac isolated MS relapse with the presentation of exertional dyspnea and superior vena cava (SVC) syndrome 3 years later. He then received radiotherapy with 24 Gy at a 12 daily fractions using forward "field in field" intensity modulated radiotherapy technique. He dramatically had improved clinical symptoms, and complete remission was achieved one month after completing radiotherapy. Our result is in line with anecdotal case reports showed that radiotherapy with 15 Gy in 10 fractions or with 24 Gy in 12 fractions resulted in good response and less toxicity of 2 cases of MS with cardiac involvement. These results indicate that a modest radiotherapy dose, 24 Gy, achieves good local control of MS with cardiac involvement. ? Journal of Thoracic Disease.
SDGs
Other Subjects
CD34 antigen; cyclosporin; cytarabine; etoposide; fludarabine; granulocyte colony stimulating factor; idarubicin; methotrexate; methylprednisolone; mitoxantrone; myeloperoxidase; stem cell factor receptor; steroid; acute myeloblastic leukemia; adult; allogeneic hematopoietic stem cell transplantation; Article; cancer control; cancer radiotherapy; cancer recurrence; cancer regression; case report; cell infiltration; chest tightness; disease association; donor lymphocyte infusion; drug safety; drug tolerability; dyspnea; eye redness; graft versus host reaction; granulocytic sarcoma; heart disease; histopathology; human; intensity modulated radiation therapy; low energy radiation; lymphadenopathy; male; multiple cycle treatment; neck dissection; nuclear magnetic resonance imaging; outcome assessment; pain; positron emission tomography; radiation response; superior cava vein syndrome; young adult
Publisher
Pioneer Bioscience Publishing
Type
journal article