Development of immunity against hepatitis B virus after donor lymphocyte infusion in a peripheral blood stem cell transplantation recipient with chronic hepatitis B
Journal
Infection
Journal Volume
39
Journal Issue
4
Pages
363-365
Date Issued
2011
Author(s)
Abstract
Hepatitis B virus (HBV) infection is one of the main concerns in blood and marrow transplantation (BMT) patients for possible breakthrough hepatitis. Active recipient immunization against HBV was found to be ineffective and many studies had showed that the adoptive transfer of immunity against hepatitis B virus would be possible by BMT with unknown duration and mechanism. A 46-year-old female patient with chronic hepatitis B had persistent detectable HBV DNA and positive serum hepatitis B e antigen (HBeAg), even while on long-term lamivudine and adefovir therapy. She received allogeneic matched unrelated donor peripheral blood stem cell transplantation (allo-MUD-PBSCT) for her refractory acute myeloid leukemia (AML). The HBV DNA became undetectable and she developed HBeAg seroconversion after PBSCT. Her hepatitis B surface antigen (HBsAg) remained positive, which disappeared later, along with the development of antibody to HBsAg after one shot of donor lymphocyte infusion (DLI) as a boost against her AML. In summary, BMT from an immunized donor would probably bring adoptive immunity against HBV. This adoptive immunity might be further enhanced by the subsequent DLI. ? 2011 Springer-Verlag.
SDGs
Other Subjects
adefovir; alanine aminotransferase; busulfan; cyclophosphamide; cytarabine; hepatitis B antibody; hepatitis B surface antigen; hepatitis B(e) antibody; hepatitis B(e) antigen; lamivudine; thymocyte antibody; virus DNA; acute granulocytic leukemia; adaptive immunity; adult; allogeneic peripheral blood stem cell transplantation; antibody blood level; article; cancer chemotherapy; cancer diagnosis; cancer regression; cancer resistance; case report; CD3+ T lymphocyte; disease exacerbation; donor lymphocyte infusion; enzyme blood level; enzyme immunoassay; graft recipient; hepatitis B; Hepatitis B virus; human; limit of detection; male; pancytopenia; peripheral blood stem cell transplantation; real time polymerase chain reaction; seroconversion; virus immunity; virus load; Adenine; Adoptive Transfer; Antiviral Agents; DNA, Viral; Drug Combinations; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Leukemia, Myeloid, Acute; Lymphocyte Transfusion; Middle Aged; Peripheral Blood Stem Cell Transplantation; Phosphonic Acids; Taiwan; Treatment Outcome; Unrelated Donors
Type
journal article