https://scholars.lib.ntu.edu.tw/handle/123456789/537990
標題: | Catastrophic gastrointestinal manifestations of post-transplant lymphoproliferative disorder | 作者: | Hsu Y.-C. WEI-CHIH LIAO HSIU-PO WANG MING YAO Lin J.-T. |
公開日期: | 2009 | 卷: | 41 | 期: | 3 | 起(迄)頁: | 238-241 | 來源出版物: | Digestive and Liver Disease | 摘要: | Post-transplant lymphoproliferative disorder is a rare complication after bone marrow transplantation and frequently involves gastrointestinal tract, but the endoscopic characteristics and catastrophic clinical manifestations in adults have not been discussed in detail. We report a 35-year-old allogeneic bone marrow transplantation recipient who presented with recurrent gastrointestinal bleeding. Ulcerative nodular lesions were noted in stomach, duodenum and ileum on endoscopy but were not biopsied because of thrombocytopenia. Obstruction and perforation of small intestine occurred 5 months after bone marrow transplantation and was managed with surgery. Histopathology revealed the diagnosis of Epstein-Barr virus related post-transplant lymphoproliferative disorder. Rituximab was given after operation but repeated intestinal perforation supervened and resulted in mortality. The characteristic endoscopic and radiographic features are presented. Recognition of these characteristic endoscopic and radiographic findings with histological confirmation is crucial in making early diagnosis, and prompt treatment may prevent gastrointestinal complications and mortality. ? 2007 Editrice Gastroenterologica Italiana S.r.l. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-60649090270&doi=10.1016%2fj.dld.2007.10.015&partnerID=40&md5=44009df825912835d0c781a575ec6222 https://scholars.lib.ntu.edu.tw/handle/123456789/537990 |
ISSN: | 1590-8658 | DOI: | 10.1016/j.dld.2007.10.015 | SDG/關鍵字: | cyclosporin A; fluconazole; foscarnet sodium; methylprednisolone; rituximab; valaciclovir; acute graft versus host disease; adult; allogenic bone marrow transplantation; article; case report; chronic myeloid leukemia; computer assisted tomography; cytomegalovirus infection; duodenum ulcer; early diagnosis; Epstein Barr virus; gastrointestinal disease; gastrointestinal endoscopy; gastrointestinal hemorrhage; herpes simplex; histopathology; human; human cell; human tissue; ileostomy; ileum disease; intestine surgery; laparotomy; lymphoproliferative disease; male; mortality; pneumoperitoneum; recurrent disease; small intestine obstruction; small intestine perforation; stomach ulcer; thrombocyte count; thrombocytopenia; thrush; virus infection; Adult; Bone Marrow Transplantation; Epstein-Barr Virus Infections; Fatal Outcome; Gastrointestinal Diseases; Humans; Lymphoproliferative Disorders; Male |
顯示於: | 醫學系 |
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